1. Which is not a tumour suppressor gene ?
A. WT-1
B. Rb
C. p53
D. RAS
Answer: D
2. Michaelis Gutmann bodies are seen in
A. >Xanthogranulomatous
B. >pyelonephritis
C. >Malakoplakia
D. Nail patella syndrome
Answer: C
3. D.I.C. is seen in :
A. >Acute promyelocytic leukemia
B. >Acute myelomonocytic leukemia
C. >CMC
D. >Autoimmune hemolytic anemia
Answer: A
4. Interleukin responsible for Pyrexia is:
A. IL1
B. IL3
C. IL4
D. IL8
Answer: A
5. Liquefactive necrosis is seen in:
A. Heart
B. Brain
C. Lungs
D. Spleen
Answer: B
6. Process of migration of leukocytes through the endothelium is through:
A. Phagocytosis
B. Pinocytosis
C. Diapedesis
D. Apoptosis
Answer: C
7. Bridging necrosis is characteristically seen in:
A. Acute hepatitis
B. Chronic hepatitis
C. Both of the above
D. None of the above
Answer: C
8. Which of the following would be the best morphological feature to distinguish ulcerative colitis from Crohn’s disease?
A. Diffuse distributions of pseudopolyps
B. Mucosal edema
C. Crypt abscesses
D. Lymphoid aggregates in the mucosa
Answer: A
9. Autosomal recessive polycystic kidney disease is characterised by the altered expression of:
A. Polycystin
B. Nephrocystin
C. Uromodulin
D. Fibrocystin
Answer: D
10. More than 90% patients of CREST syndrome with the limited cutaneous form of this disorder make which of the following autoantibodies?
A. Anti-centromere
B. Anti-DNA topoisomerase l
C. Anti-double-stranded DNA
D. Anti-Golgi
Answer: A
11. 1 to 2 mm haemorrhages in skin are known as:
A. Micro bleed
B. Petechiae
C. Purpura
D. None of the above
Answer: B
12. ‘Flare’ in Triple response is mediated by :
A. Axon reflex
B. Arteriolar dilation
C. Histamine release
D. Local hormones
Answer: A
13. Medial calcification is seen in A. Atherosclerosis
B. Arteriolosclerosis
C. Monckebergs sclerosis
D. Dissecting aneurysm
Answer: C
14. Changes seen in atherosclerotic plaque at the time of rupture are all except
A. Thin fibrosis cap
B. Multiple foam cap
C. Smooth muscle cell hypertrophy
D. Cell debris
Answer: C
15. Atheromatous changes of blood vessels
affects early in A. Kidney
B. Heart
C. Liver
D. Spleen
Answer: B
16. Which of the following is a non-modifiable risk factor for CHD
A. Diabetes
B. Smoking
C. Hypertension
D. Old age
Answer: D
17. Most common cause of dissecting hematoma is because of
A. Hypertension
B. Marfan’s
C. Iatrogenic
D. Kawasaki
Answer: A
18. Cystic medial necrosis is seen in
A. Marfans syndrome
B. Friedrichs ataxia Pattern
C. Downs syndrome
D. Kawasaki disease
Answer: A
19. Small vessel vasculitis are
A. Classical PAN
B. Wegner’s granulomatosis
C. Giant cell arteritis
D. All
Answer: B
20. All is true about Giant cell arteritis except ?
A. Involves large to small sized areteries
B. Granulomatous inflammation
C. Most commonly involved artery is abdominal aorta
D. Segmental nature of the involvement
Answer: C
21. Raynaud’s phenomenon what change is seen in vessels initial stage
A. No change (Fibrinoid, Thrombosis)
B. Thrombosis
C. Fibrinoid necrosis
D. Hyaline sclerosis
Answer: A
22. The tissue of origin of the Kaposi’s sarcoma is ?
A. Lymphoid
B. Vascular
C. Neural
D. Muscular
Answer: B
23. Concentric hypertrophy of left ventricle is seen in
A. Cong. bicuspid aortic valve
B. MS
C. AR
D. HOCM
Answer: A
24. Which one of the following sets of components of cigarette smoke is a causal agent of coronary artery disease
A. Tar and nicotine
B. Nicotine and carbon monoxide and tar
C. Carbon monoxide and Tar
D. Carbon dioxide
Answer: B
25. Earliest histological change in MI
A. Macrophage infiltration
B. Neutrophilic infiltration
C. Waviness of fibers
D. Coagulative necrosis
Answer: C
26. 7 day old MI the most sensitive biochemical marker
A. Troponin I T
B. CPK MB
C. LDH
D. Myoglobin
Answer: A
27. Which is not seen in Aschoff bodies
A. Giant cells
B. Aschoff cells
C. Fibroblasts
D. Polymorphonuclear cells
Answer: D
28. Vegetations in libman sacendocarditis are ?
A. Large and fragile
B. Small warty along the line of closure of valve
C. Small or medium sized on either or both sides of valve
D. Small bland vegetations
Answer: C
29. Causes of constrictive pericarditis is/are ?
A. T.B.
B. SLE
C. Brucellosis
D. a and b
Answer: D
30. Hypertrophy is A. Increase in cell number
B. Increase in cell size
C. Decrease in cell number
D. Decrease in cell size
Answer: B
31. Physiological hyperplasia and hypertrophy are seen simultaneously in
A. Uterus in pregnancy
B. Skeletal muscle in atheleteas
C. Breast at puberty
D. a and c
Answer: D
32. The sign of reversible injury in a case of alcoholic liver disease
A. Loss of cell membrane
B. Nuclear karyolysis
C. Cytoplasmic vacuole
D. Pyknosis
Answer: C
33. In cell death, myelin figures, are derived from
A. Nucleus
B. Cell membrane
C. Cytoplasm
D. Mitochondria
Answer: B
34. Enzyme that protects the brain from free radical injury is
A. Myeloperoxidase
B. Superoxide dismutase
C. MAO
D. Hydroxylase
Answer: B
35. MI is a type of
A. Coagulative necrosis
B. Liquefactive necrosis
C. Caseous necrosis
D. Fat necrosis
Answer: A
36. Fat necrosis is common in
A. Omentum
B. Breast
C. Retroperitoneal fat
D. All of the above
Answer: D
37. Programmed cell death is known as
A. Cytolysis
B. Apoptosis
C. Necrosis
D. Proptosis
Answer: B
38. In apoptosis, cytochrome C acts through
A. Apaf 1
B. Bcl-2
C. FADD
D. TNF
Answer: A
39. Which is activated for nuclear fragmentation in apoptosis
A. Caspases
B. Apaf – 1
C. Oxygen free radicals
D. All
Answer: A
40. In apoptosis which is/are involved
A. Apaf-1
B. Bc12
C. Caspases
D. All
Answer: D
41. Annexin Visa marker of
A. Apoptosis
B. Necrosis
C. Artherosclerosis
D. Inflammation
Answer: A
42. Dystrophic calcification is seen in ?
A. Milk alkali syndrome
B. Atheromatous plaque
C. Hyperparathyroidism
D. Vitamin A intoxication
Answer: B
43. Calcification of soft tissues without any disturbance of calcium metabolism is called
A. Ionotropic calcification
B. Monotropic calcification
C. Dystrophic calcification
D. Calcium induced calcification
Answer: C
44. True about gastric lymphoma
A. Non Hodgkins lymphoma commonest variety
B. Diagnosis is made by biopsy
C. H-Pylori has direct relationship
D. All
Answer: D
45. Most common site of GIST is
A. Ileum
B. Esophagus
C. Colon
D. Stomach
Answer: D
46. Which of the following markers is specific for gastro-intestinal stomal tumor (GIST)
A. CD 117
B. CD 34
C. CD 23
D. S-100
Answer: A
47.Aganglionic segment is encountered in which part of colon in case of Hirschsprung disease ?
A. Distal to dilated segment
B. In Whole colon
C. Proximal to dilated segment
D. In the dilated segment
Answer: A
48. Multiple epidermoid cysts are seen in
A. Turcot’s syndrome
B. Gardner’s syndrome
C. Peutz-Jegher syndrome
D. Familial polyposis coli
Answer: B
49. Features of Peutz-Jeghers syndrome are all except?
A. Autosomal dominant
B. Mucocutaneous pigmentation
C. Hamartomatous polyp
D. High risk of malignacy
Answer: D
50. The features of crohns disease are all except ?
A. Lymphoid hyperplasia
B. Skin lesion
C. Transmural involvement
D. Crypt Abscess
Answer: A
51. Female is affected, male is not. Disease is autosomal dominant, what is the chance in children?
A. 50% affected
B. 25% affected
C. 75% affected
D. All affected
Answer: A
52. Chance of having cystic fibrosis if only one parent is affected and other is normal
A. 25%
B. 50%
C. 70%
D. 80%
Answer: B
53. True statement about inheritance of an X linked recessive trait is
A. 50% of boys of carrier mother are affected
B. 50% of girls of diseased father are carrier
C. Father transmits disease to the son
D. Mother transmits the disease to the daughter
Answer: A
54. Normal female, whose father was colour blind married a normal man. What are the chances of colour blindness in son
A. 25%
B. 50%
C. 75%
D. No chance
Answer: B
55. The inheritance pattern of familial Retinoblastomas is
A. Autosomal recessive
B. Autosomal dominant
C. X-linked dominant
D. X-linked recessive
Answer: B
56. Male to male transmission is seen in
A. Autosomal dominant diseases
B. Autosomal recessive
C. X-linked dominant
D. M itochondrial disease
Answer: A
57. Single gene disorder which does not follow mendelian inheritance
A. Sickle cell anemia
B. Down syndrome
C. Fragile X-syndrome
D. Retinoblastoma
Answer: C
58. Transport of lipids from the intestine to other tissues is by
A. Chylomicrons
B. LDL
C. HDL
D. VI DL
Answer: A
59. Which is not a feature of Downs syndrome
A. Clinodactyly
B. Pigmented birth marks
C. Hypotonia
D. Respiratory tract Infections
Answer: B
60. Following injury to a blood vessel, immediate haemostasis is achieved by
A. Fibrin deposition
B. Vasoconstriction
C. Platelet adhesion
D. Thrombosis
Answer: B
61. Lines of Zahn occur in
A. Postmortem clot
B. Infarct
C. Embolus
D. Coralline thrombus
Answer: D
62. Anemia with reticulocytosis is seen in
A. Hemolysis
B. Iron deficiency anemia
C. Vitamin B12 deficiency
D. Aplastic anemia
Answer: A
63. Intravascular hemolysis occurs in
A. Hereditary spherocytosis
B. Acute G6PD
C. Sickle cell ds
D. b and c
Answer: D
64. Maximum spherocytes is seen in
A. Autoimmune haemolytic anemia
B. Vit B12 deficiency
C. Aplastic anemia
D. None
Answer: A
65. The primary defect which leads to sickle cell anemia is
A. An abnormality in porphyrin part of hemoglobin
B. Replacement of glutamate by valine in n-chain of HbA
C. A nonsence mutation in the I3-chain of HbA
D. Substitution of valine by glutamate in the a-chain of HbA
Answer: B
66. Which is not a feature of paroxysmal nocturnal haemoglobinuria
A. Increased LAP score
B. Thrombosis
C. Thrombocytopenia
D. Hemolysis
Answer: A
67. Cold agglutinin is
A. IgG
B. IgM
C. IgA
D. IgD
Answer: B
68. Response to iron in iron deficiency anaemia is denoted by
A. Restoration of enzymes
B. Reticulocytosis
C. Increase in iron binding capacity
D. Increase in hemoglobin
Answer: B
69. Megaloblastic anemia is seen in ?
A. ileal resection
B. Crohn’s disease
C. Intestinal lymphatic ectasia
D. a and b
Answer: D
70. The anaemia associated with leukaemia is ?
A. Iron deficiency
B. Megaloblastic type
C. Myelophthisic type
D. All of above
Answer: C
71. Schistocyte is/are found in
A. TTP
B. DIC
C. Severe iron deficiency
D. All
Answer: D
72. Helmet cells are characteristic of anemia of?
A. Hemolytic uremic syndrome
B. Polysplenia
C. Spherocytosis
D. Acanthocytosis
Answer: A
73. Gamma gandy bodies are seen in all except ?
A. Cirrhosis with portal hypertension
B. Chronic myeloid leukemia
C. Sickle cell anemia
D. Thalassemia
Answer: D
74. Increased permeability in acute inflammation is due to
A. Histamine
B. IL-2
C. TGF-P
D. FGF
Answer: A
75. which of the following does not belong to the family of selectin?
A. P selectin
B. L selectin
C. A selectin
D. E selectin
Answer: C
76. Cell-matrix adhesions are mediated by?
A. Cadherins
B. Integrins
C. Selectins
D. Calmodulin
Answer: B
78. Maximum collagen in wound healing is seen at
A. End of first week
B. End of second week
C. End of third week
D. End of 2 months
Answer: B
79. Chemotaxis is mediated by
A. Histamine
B. Leukotriene B4 and C5a
C. Leukotriene C4 and C3a
D. Bradykinin
Answer: B
80. Following injection of lymphokines, the same class of immunoglobulin are produced. This is to be referred as
A. Group switching
B. Clonal selection
C. Hybridisation
D. Class switching
Answer: B
81. Most potent stimulator of Naïve T-cells
A. Mature dentritic cells
B. Follicular dentritic cells
C. Macrophages
D. B-cell
Answer: A
82. True about MHC-class II
A. Not involved in innate immunity
B. Cytotoxic T-cell involved
C. Present in nucleated cells
D. All
Answer: A
83. Common variable hypogammaglobulinemia shows ?
A. Decreased B cell count
B. Increased B cell count
C. Compliment opsinization
D. Neutropenia
Answer: C
84. Major fibril protein in Primary Amyloidosis is
A. AL
B. AA
C. Transthyretin
D. Procalcitonin
Answer: A
85. Which type of Amyloidosis is caused by mutation of the transthyretin protein ?
A. Familial Mediterranean fever
B. Familial amyloidotic polyneuropathy
C. Dialysis associated amyloidosis
D. Prion protein associated amyloidosis
Answer: B
86. Amyloidosis is most commonly seen in ?
A. Maturity onset DM
B. Type I DM
C. Type II DM
D. HTN
Answer: C
87. Serum amyloid associated protein, found in ?
A. Alzheimer’s disease
B. Chronic inflammatory states
C. Chronic renal failure
D. Malignant hypertension
Answer: B
88. Hamartoma is
A. Malignant tumor
B. Metastatic tissue
C. Development malformation
D. Hemorrhage in vessel
Answer: C
89. Overgrowth of a skin structure at a localised region
A. Hamartoma
B. Malignant tumor
C. Choriostoma
D. All
Answer: A
90. Excessive fibrosis in tumor in called
A. Anaplasia
B. Metaplasia
C. Desmoplasia
D. Dysplasia
Answer: C
91. When stem cells transforms to form cells characteristic of other tissues, the process is called as
A. De-differentiation
B. Re-differentiation
C. Trans-differentiation
D. Sub-differentiation
Answer: C
92. Carcinoma of lung, breast marker is
A. CEA
B. AFP
C. 11CG
D. CA-15-3
Answer: A
93. AFP is raised in
A. Yolk sac tumor
B. Seminoma
C. Teratoma
D. a and c
Answer: D
94. Elevated CA-125 are seen in
A. Abdominal TB
B. Ca cervix
C. Endometriosis
D. All
Answer: D
95. The tumor suppressor gene P53 induces cell arrest at
A. M phase
B. S – G2 phase
C. G1 – S phase
D. Go – phase
Answer: C
96. Major contribution to cachexia with advanced cancer?
A. Catherin
B. Histamine
C. Interferon
D. Tumour-necrosis-factor (TNF)
Answer: D
97.Hemolytic Uremic Syndrome is characterized by ?
A. Microangiopathic haemolytic anaemia
B. Positive Coomb’s test
C. Thrombocytopenia
D. a and c
Answer: D
98. All are features of haemolytic uremic syndrome, except
A. Hyperkalaemia
B. Anaemia
C. Renal microthrombi
D. Neuro psychiatric disturbances
Answer: D
99. In DIC, following are seen except
A. Fibrinogen decreased
B. Thrombocytopenia
C. Normal APTT
D. PT elevation
Answer: C
100. Shelf life of blood with CPDA A. 2 weeks
B. 3 weeks
C. 5 weeks
D. 8 weeks
Answer: C
101. Which of the following is not true about idiopathic thrombocytopenic purpura?
A. Antibodies of IgM class
B. Autoantibodies to Gp IIb/ Ilia or IB IX
C. Increased megakaryocytes in bone marrow
D. Spleen is normal in size
Answer: A
102. Macrophage activation syndrome characterized by all except ?
A. Activation of CD 8 + T cells
B. Presence of cytokine storm
C. It is the other name for hemophagocytic lymph histiocytosis
D. Low levels of plasma ferretin
Answer: D
103. HLA associated with rheumatoid arthritis is ?
A. HLA B27
B. HLA DR 4
C. HLABI9
D. HLA DR2
Answer: B
104. Hepatitis B associated with ?
A. Wegener’s granulomatosis
B. Systemic lupus erythematosus
C. Polyarteritis nodosa
D. Sjogren syndrome
Answer: C
105. Normal upper limit of CA – 125 is ?
A. 25 U/ ml
B. 45 U/ ml
C. 65 U/ ml
D. 85 U/ ml
Answer: A
106. Which of the following interleukin is secreted by T helper 2 cells?
A. IL 11
B. IL 7
C. IL 1
D. IL 13
Answer: D
107. Atopy in hypersensitivity is ?
A. Systemic type I hypersensitivity
B. Local type I hypersensitivity
C. Systemic type II hypersensitivity
D. Local type II hypersensitivity
Answer: B
108. Inheritance pattern of myotonic
dystrophy is ?
A. Autosomal recessive
B. Autosomal dominant
C. X linked dominant
D. X linked recessive
Answer: B
109. Gene responsible for Wilson disease is situated on which chromosome?
A. Chromosome 11
B. Chromosome 12
C. Chromosome 13
D. Chromosome 14
Answer: C
110. Antischkow cells are ?
A. Modified macrophages
B. Modified neutrophils
C. Modified B cells
D. Modified RBCs
Answer: A
111. Patient with chronic hypertension will show following changes on histology of kidney
A. Hyaline arteriosclerosis
B. Hyperplastic arteriosclerosis
C. Onion skin lesions
D. Vessel lumen dilatation
Answer: A
112. NK cell shows presence of ?
A. CD 44
B. CD 16
C. CD 54
D. CD 32
Answer: B
113. Non professional antigen presenting cell is A/E ?
A. Endothelial cell
B. Epidermal cell
C. Fibroblasts
D. Red blood cells
Answer: D
114. Blood is stored at what temperature in blood bank?
A. -2 to -4 degrees Celsius
B. -2 to 0 degrees Celsius
C. 1 to 6 degrees Celsius
D. 6 to 12 degrees Celsius
Answer: C
115. Birbeck granules in cytoplasm is seen in ?
A. Langerhans cell histiocytosis
B. Hodgkin’s lymphoma
C. Non hodgkins lymphoma
D. Gastrointestinal stromal tumor
Answer: A
116. Reticulocytes are stained by ?
A. Supravital stain
B. Purssian blue stain
C. H and E stain
D. Reticulin stain
Answer: A
117. Most common type of Hodgkin’s lymphoma is ?
A. Lymphocyte predominant
B. Lymphocyte depletion
C. Nodular sclerosis
D. Mixed cellularity
Answer: C
118. Most common site for eosinophilic granuloma is?
A. Radius
B. Skull
C. Lumbar vertebra
D. Femur
Answer: B
119. Replacement of columnar epithelium in respiratory tract to squamous epithelium is ?
A. Hyperplasia
B. Hypoplasia
C. Metaplasia
D. None of the above
Answer: C
120. Which is the best marker of SLE ?
A. Anti Sm antibodies
B. Anti dsDNA antibodies
C. Anti histone antibodies
D. Anti Ro Antibodies
Answer: B
121. Most common cause of death in amyloidosis is ?
A. Heart failure
B. Renal failure
C. Sepsis
D. None
Answer: A
122. What is true about ulcerative colitis ?
A. Involves rectum and then whole colon backwards
B. Involves only colon
C. Skip lesions seen
D. Ileum not involved
Answer: A
123. Execution caspases of apoptosis are ?
A. Caspase 1 & 3
B. Caspase 3 & 5
C. Caspase 1 & 5
D. Caspase 3 & 7
Answer: D
124. Neurofibromatosis shows which of the following mode of inheritance ?
A. AD
B. AR
C. X linked dominant
D. X linked recessive
Answer: A
125. Most common site of glomus tumor is ?
A. Under fingernails
B. Under toenails
C. Neck
D. Axilla
Answer: A
126. Normal reticulocyte count in new-born is
A. 0 – 1%
B. 1 – 1.5%
C. 3 – 6%
D. 6 – 9 %
Answer: C
127. BRCA2 not associated with
A. breast cancer
B. Prostate cancer
C. Ovarian cancer
D. Vulval cancer
Answer: D
128. Which of the following is not a large vessel vasculitiis ?
A. Takayasu arteritis
B. Cogan syndrome
C. Chrug strauss syndrome
D. Giant cell arteritis
Answer: C
129. Trauma to breast causes which type of necrosis ?
A. Coagualtive necrosis
B. Liquefactive necrosis
C. Caseous necrosis
D. Fat necrosis
Answer: D
130. Inhibin is tumor marker for ?
A. Granulosa cell tumor
B. Malignant melanoma
C. Prolactinoma
D. Breast carcinoma
Answer: A
131. Following statement is true for haemophilia patients?
A. All Females are carriers and all males are affected
B. All Males are carriers and all females are affected
C. Females are mostly carriers and all males are affected
D. Males are mostly carriers and all females are affected
Answer: C
132. Which worm causes myocarditis ?
A. Trichuris
B. Trichinella
C. Enterobius
D. Strogyloides
Answer: B
133. Giant platelets are seen in ?
A. Bernard soulier syndrome
B. vWD
C. Polycythemia rubra vera
D. Leukemia
Answer: A
134. LE cell is seen in ?
A. Lupus erythmatosus
B. Lupus vulgaris
C. HNPCC
D. Medullary carcinoma of thyroid
Answer: A
135. Pelger Huet anamoly shows presence of ?
A. Hyposegmented neutrophil
B. Hypersegmented neutrophil
C. Unsegmented neutrophil
D. None of the above
Answer: A
136. Sentinel lymph node biopsy is used for ?
A. Melanoma
B. Basal cell carcinoma
C. Squamous cell carcionoma
D. Thyroid carcinoma
Answer: A
137. Interleukin 2 is produced by
A. T helper cells 1
B. T helper cells 2
C. Natural killer cells
D. Basophils
Answer: A
138. Popcorn cells are seen in which variety of Hodgkin’s disease ?
A. Nodular sclerosis
B. Mixed cellularity
C. Lymphocyte predominant
D. Lymphocyte depletion
Answer: C
139. Shape of birbeck granules is ?
A. Tennis racket
B. Hockey stick
C. Bat
D. Ball
Answer: A
140. Lipid peroxidation of polyunsaturated lipids of subcellular membranes produces ?
A. Lipofuscin
B. Hemosiderin
C. Both of above
D. None of above
Answer: A
141. Paraneoplastic syndrome Hypercalcemia of malignancy, is produced due to ectopic production of which hormone by lymphomas ?
A. PTHrP
B. 1,25 dihydroxyvitamin D
C. PGE2
D. Parathormone
Answer: B
142. HLA B51 is associated with ?
A. Behcet’s disease
B. Chrug strauss syndrome
C. Microscopic polyangitis
D. Polyarteritis nodosa
Answer: A
143. PT is used to test ?
A. Extrinsic and common pathway
B. Intrinsic and common pathway
C. Intrinsic pathway
D. Extrinsic pathwa
Answer: A
144. Which of the following is not a hereditary disease?
A. Neurofibromatosis
B. Cretinism
C. Huntingtons disease
D. Hereditary spherocytosis
Answer: B
145. Point mutaton in which protooncogene is responsible for the development of gastrointestinal stromal tumour
A. KIT
B. ALK
C. RET
D. FLT3
Answer: A
146. Carcinoembryonic antigen is raised in which of the following non neoplastic conditions
A. Hepatitis
B. Pancreatitis
C. Haemolytic anaemia
D. Ulcerative colitis
Answer: B
147. Under Blood safety programme compulsory tests done are all except ?
A. HIV
B. VDRL
C. Malaria
D. Hepatitis E
Answer: D
148. EBV receptor mimics ?
A. CD 20
B. CD 21
C. CD 22
D. CD 23
Answer: B
149. Leukocyte adhesion to endothelium is mediated by all except ?
A. L selectin
B. E selectin
C. VCAM 1
D. VCAM 4
Answer: D
150. Boys are more likely to be affected by which genetic disorders ?
A. AD
B. AR
C. X linked dominant
D. X linked recessive
Answer: D
151. Inceased accumulation of fluid in the interstitial space is described as ?
A. Edema
B. Effusion
C. Transudate
D. Exudate
Answer: A
152. Classic example of missense mutation ?
A. Thalassemia
B. Sickle cell disease
C. Sideroblastic anemia
D. Hemochromatosis
Answer: B
153. Matrix metalloproteinases is ?
A. Cathepsin
B. Zn metalloproteinases
C. Cu metalloproteinases
D. Cd metalloproteinases
Answer: A
154. Tau protein seen in ?
A. Alzhiemer’s disease
B. Lewy body dementia
C. Picks disease
D. Amylodosis
Answer: A
155. The phenomenon by which the cancer cells are able to sustain and proliferate under adverse conditions of hypoxia is ?
A. Warburg
B. Wanton
C. Wormian
D. Wolf
Answer: A
156. Defect of Glanzmann’s thrombasthenia is ?
A. Gp1Ib-IlIa
B. GpIIIa-I lb
C. GpIla-Illb
D. Gpfilb-I la
Answer: A
157. Metastatic calcification is characterized by ?
A. Hypercalcemia
B. Hypocalcemia
C. Eucalcemia
D. None of the above
Answer: A
158. Most important growth factors in angiogenesis ?
A. PDGF
B. TGF alpha
C. TGF beta
D. VEGF
Answer: D
159. Necrosis with cell bodies retained as ghost cells is ?
A. Coagulative necrosis
B. Liquefactive
C. Caseous
D. None
Answer: A
160. Cells responsible for GVHD is ?
A. Immunocompetent T cell donor
B. Immunocompetent T Cell recipient
C. Immunocompetent B cell donor
D. Immunocompetent B cell donor
Answer: A
161. Flow cytometry is done on
A. Polycythaemia
B. Thrombocytosis
C. Basophil
D. Lymphocytes
Answer: D
162. Person having heterozygous sickle cell trait is protected from infection of:
A. P. falciparum
B. P. vivax
C. Pneumococcus
D. Salmonella
Answer: A
163. Sequence of events in acute inflammation ?
A. Vasodilatation → Stasis → Transient vasoconstriction → Increased permeability
B. Transient vasoconstriction → Stasis → Vasodilatation → Increased permeability
C. Transient vasoconstriction → Vasodilatation → Stasis → Increased permeability
D. Transient vasoconstriction →Vasodilatation → Increased permeability → Stasis
Answer: D
164. Gene silencing RNA ?
A. rRNA
B. tRNA
C. miRNA
D. None
Answer: C
165. All are obstructive lung disease except
A. Emphysema
B. Interstitial fibrosis
C. Asthma
D. Bronchitis
Answer: B
166.Centrilobular necrosis of liver may be seen with?
A. Phosphorus
B. Arsenic
C. CCI4
D. Ethanol
Answer: C
167. During angiogenesis recruitment of pericytes and periendothelial cells is due to
A. VEGF & PDGF
B. Angiopoietins, TGF & PDGF
C. TGF, VEFG & PDGF
D. VEGF, IL-6
Answer: B
168. Heart failure cells are ?
A. Lipofuscin granules in cardiac cells
B. Pigmented alveolar macrophages
C. Pigmented pancreatic acinar cells
D. Pigment cells seen in liver
Answer: B
169. All are true about Polycythaemia vera except
A. Increased vit B12
B. Decrease LAP score
C. Leucocytosis
D. Increased platelets
Answer: B
170. Intracorpuscular hemolytic anemia is seen in ?
A. Autoimmune hemolytic anemia
B. TIP
C. Thalassemia
D. Infection
Answer: C
171. Gilbert syndrome, true all except ?
A. Causes cirrhosis
B. Autosomal dominant
C. Normal liver function test
D. Normal histology
Answer: A
172. Flexner-Winter Steiner rosette is seen in
A. Hepatoblastoma
B. Nephroblastoma
C. Neuroblastoma
D. Retinoblastoma
Answer: D
173. Band test is done in ?
A. RA
B. SLE
C. Scleroderma
D. PAN
Answer: B
174. Angelman syndrome is due to
A. Digenic inheritance
B. Inversion
C. Uniparental disomy
D. Mitochondrial disorder
Answer: C
175. Organelle where H202 is produced and destroyed is?
A. Peroxisome
B. Lysosome
C. Golgi body
D. Ribosome
Answer: A
176. Increased permeability in acute inflammation is due to?
A. Histamine
B. IL-2
C. TGF-(3
D. FGF
Answer: A
177. Not true about hereditary spherocytosis
A. Defect in ankyrin
B. Decreased MCV
C. Decreased MCHC
D. Reticulocytosis
Answer: C
178. Mantle cell lymphomas are positive for all of the following, except ?
A. CD 23
B. CD 20
C. CD 5
D. CD 43
Answer: A
179. Gastric carcinoma is associated with all EXCEPT ?
A. Inactivation of p53
B. Over expression of C-erb
C. Over expression of C-met
D. Activation of RAS
Answer: D
180. Irreversible injury in myocardium occurs at ?
A. 2 minutes
B. 30 minutes
C. 2 hours
D. 5 hours
Answer: B
181. Bone marrow finding in myelofibrosis ?
A. Dry tap (hypocellular)
B. Megaloblastic cells
C. Microcytic cells
D. Thrombocytosis18
Answer: A
182. Schiller- Duval bodies is seen in
A. Choriocarcinoma
B. Embryonal cell Ca
C. Endodermal sinus tumour
D. Immature teratoma
Answer: C
183. A/E are involved in MEN type II A ?
A. Parathyroid
B. Adrenal
C. Thyroid
D. Pituitary
Answer: D
184. All are good prognostic factors for neuroblastoma except
A. Trk-A expression absent
B. Absence of 1 p loss
C. Absence of 17 p gain
D. Absence of 11 q loss
Answer: A
185. Eosinophilia in necrosed tissue is due to
A. Coagulation of proteins
B. Denaturation of enzymes
C. Denaturation of protein
D. Mitochondrial damage
Answer: C
186. Macrophages are converted to epithelioid cells by which cytokine ?
A. IL-2
B. IFN-y
C. TNF-a
D. TGF-(3
Answer: B
187. The professional antigen presenting cells ?
A. B cells
B. Dendritic cells
C. T cells
D. NK cells
Answer: B
188. All are growth promoting oncogenes except ?
A. FGF
B. TGF-a
C. TGF-p
D. PDGF
Answer: C
189. Hyperplastic arteriolitis with nerotizing arteriolitis is seen in ?
A. Buerger’s disease
B. Benign hypertension
C. Malignant hypertension
D. Diabetes
Answer: C
190. Fibrosis is due to ?
A. TGF
B. TNF
C. IL – 7
D. IL – 10
Answer: A
191. In sickle cell anemia all are true except
A. Sickle cells
B. Target cells
C. Howell jolly bodies
D. Ringed sideroblast
Answer: D
192. Linitis plastica is a type of ?
A. Plastic like lining of stomach
B. Diffuse carcinoma of stomach
C. Benign ulcer
D. GIST
Answer: B
193. Microvesicular fatty liver is caused by ?
A. DM
B. Valproate
C. Starvation
D. IBD
Answer: B
194. Localised langerhans cells histiocytosis affecting head & neck is ?
A. Letterer-siwe disease
B. Pulmonary langerhans cell histiocytosis
C. Hand-schuller-christian disease
D. Eosinophilic granuloma
Answer: D
195. Which cytokine activate macrophages ?
A. IL-8
B. IFN-y
C. PAF
D. Leukotriene B4
Answer: B
.
196. Syphilitic aneurysm mostly involve ?
A. Arch of aorta
B. Descending aorta
C. Abdominal aorta above the renal arteries
D. Abdominal aorta below the renal arteries
Answer: A
197. Hurthle cell carcinoma is a variant of ?
A. Medullary carcinoma
B. Papillary carcinoma
C. Follicular carcinoma
D. Anaplastic carcinoma
Answer: C
198. HLA is located on ?
A. Short arm of chr-6
B. Long arm of chr-6
C. Short arm of chr-3
D. Long arm of chr-3
Answer: A
199.Classification of aortic dissection depends upon?
A. Cause of dissection
B. Level of aorta affected
C. Percentage of aorta affected
D. None
Answer: B
200. Thalassemia gives protection against ?
A. Filaria
B. Kala-azar
C. Malaria
D. Leptospirosis
Answer: C
201. Maltoma is positive for?
A. CD 3
B. CD 10
C. CD 23
D. CD 5
Answer: C
202. Terminal stage of pneumonia is
A. Congestion
B. Red hepatization
C. Gray hepatization
D. Resolution
Answer: D
203. Intestinal angiodysplasia involves ?
A. AV malformation
B. Cavernous hemangioma
C. Capillary hemangioma
D. Malignant tumor
Answer: A
