1. Regarding Caisson’s disease which statement among the following is CORRECT?
A. Lung damage is caused by air embolism
B. Pain in the joints is due to nitrogen bubbles
C. Tremors are seen due to nitrogen narcosis
D. High pressure Nervous syndrome can be prevented by using mixtures of Oxygen & Helium
Answer: B
2. Preload measures?
A. End systolic volume
B. End diastolic volume
C. Peripheral resistance
D. Stroke volume
Answer: B
3. Central Chemoreceptors are most sensitive to following changes in blood:
A. TPCO2
B. I PCO2
C. TH+
D. T PO2
Answer: A
4. Which of the following statement is TRUE about Bohr’s effect?
A. Decreased affinity of Hb to 02 is associated with decreased pH & increased C02
B. Decreased affinity of Hb to 02 is associated with increased pH & decreased C02
C. Decreased affinity of Hb to 02 is associated with decreased pH & C02
D. Decreased affinity of Hb to 02 is associated with increased pH & C02
Answer: A
5. Glands are classified depending upon their mode of secretion. Sebaceous gland is an example of which of the following type of gland?
A. Eccrine
B. Apocrine
C. Holocrine
D. Paracrine
Answer: C
6. Ruffini end organ is associated with sensation of:
A. Sustained Pressure
B. Heat
C. Touch
D. None of the above
Answer: A
7. Lower esophageal sphincter pressure is increased by all of the followingsubstances, EXCEPT:
A. Gastrin
B. Vasopressin
C. Glucagon
D. Secretin
Answer: D
8. Colipase is:
A. Is secreted by Oxyntic cells
B. Is secreted in the active form
C. Helps gastric lipase
D. Encoded by the gene CLPS
Answer: D
9. Iron absorption is increased by the following factor in diet:
A. Vitamin-C
B. Phytic acid
C. Fibre diet
D. Phosphates
Answer: A
10. Which of the following statement regarding lower esophageal sphincter is TRUE?
A. It has no tonic activity
B. It has a tone which is provided by the sympathetic system
C. Relaxes on increasing abdominal pressure
D. Relaxes ahead of the peristaltic wave
Answer: D
11. True about volume receptors are all, EXCEPT:
A. They are low pressure receptors
B. They provide afferents for thirst control
C. They are located in carotid sinus
D. They mediate vasopressin release
Answer: C
12. In an ECG the cardiac event corresponding to the ST segment is:
A. Atrial depolarisation
B. Ventricular depolarisation
C. Atrial repolarisation
D. Ventricular repolarisation
Answer: D
13. Which one of the following is the CORRECT statement regarding coronary blood flow?
A. Coronary blood flow is directly related to perfusion pressure and inversely related to resistance
B. Coronary blood flow is inversely related to perfusion pressure and directly related to resistance
C. Coronary blood flow is directly related to perfusion pressure and also to resistance
D. Coronary blood flow is inversely related to both pressure and resistance
Answer: A
14. Depressor reflex, Bezold-Jarisch reflex, produced by the following stimulus:
A. Atrial overload
B. Myocardial infarction
C. Ventricular distension
D. Isotonic exercise
Answer: C
15. All of the following cell types undergo cell division, EXCEPT:
A. Pericyte
B. Cardiac muscle cell
C. Smooth muscle cell
D. Satellite cell of skeletal muscle
Answer: B
16. Direct Fick method of measuring cardiac output requires estimation of:
A. O2 content of arterial blood
B. O2 consumption per unit time
C. Arteriovenous O2 difference
D. All of the above
Answer: D
17. Primitive red cells first originates in the early embryonic life is in:
A. Liver
B. Yolk sac
C. Bone marrow
D. Spleen
Answer: B
18. Transpulmonary pressure is the difference between:
A. The bronchus and atmospheric pressure
B. Pressure in alveoli and intrapleural pressure
C. Atmosphere and intrapleural pressure
D. Atmosphere and intraalveolar pressure
Answer: B
19. What is the partial pressure of oxygen at 760mmHg atmospheric pressure?
A. 76
B. 160
C. 120
D. 130
Answer: B
20. The primary active step for sodium reabsorption in the proximal tubule involves:
A. Sodium-glucose cotransport across the luminal membrane
B. Sodium/hydrogen ion counter transport across the luminal membrane
C. Sodium transport via the Na+-K+-ATPase at the basolateral membrane
D. Sodium-amino acid cotransport across the luminal membrane
Answer: C
21. Angiotensin II causes all of the following, EXCEPT:
A. Stimulation of thirst
B. Aldosterone secretion
C. Increased ADH secretion
D. Vasodilation
Answer: D
22. Which of the following is the cause of nonshivering thermogenesis in adults?
A. Noradrenaline
B. Thyroid hormone
C. Muscle metabolism
D. Brown fat between the shoulders
Answer: A
23. The nucleus involved in Papez circuit is:
A. Pulvinar
B. Intralaminar
C. VPL nucleus
D. Anterior nucleus of Thalamus
Answer: D
24. Which of the following is NOT TRUE about CSF?
A. Removal of CSF during dural tap causes intense intracranial headache
B. Normally contain no neutrophils
C. Formed by arachnoid villi within the ventricles
D. pH is less than that of plasma
Answer: C
25. Cerebral blood flow is regulated by all, EXCEPT:
A. Intracranial pressure
B. Arterial PC02
C. Potassium ions
D. Cerebral metabolic rate
Answer: C
26. Withdrawal reflex is an example of which of the following?
A. Monosynaptic reflex
B. Polysynaptic reflex
C. Both A and B of the above
D. None of the above
Answer: B
27. Which of the following is referred to as the “Window of the limbic system”?
A. Hypothalamus
B. Amygdala
C. Hippocampus
D. Thalamus
Answer: B
28. Broca’s area is concerned with:
A. Word formation
B. Comprehension
C. Repetition
D. Reading
Answer: A
29. Nucleus of basal ganglia
A. Dentate
B. Thalamus
C. Caudate
D. Red nucleus
Answer: C
30. Resting membrane potential in nerve fibre
A. Is equal to the potential of ventricular muscle fibre
B. Can be measured by surface electrodes
C. Increases as extra cellular K+ increases
D. Depends upon K+ equilibrium
Answer: D
31. Alveolar hypoventilation is present in A/E:
A. Bulber poliomyelitis
B. COPD
C. Kyphoscoliosis
D. Lobar pneumonia
Answer: D
32. Which of the following does NOT stimulate peripheral chemoreceptors:
A. Hypoxia
B. Hypocapnia
C. Acidosis
D. Low perfusion pressure
Answer: B
33. Stability of alveoli is maintained by?
A. Lung compliance
B. Negative intrapleural pressure
C. Increase in alveolar surface area by the surfactant
D. Residual air in alveoli
Answer: C
34. Mean arterial pressure is calculated as:
A. (SBP + 2DBP)/ 3
B. (DBP + 2SBP)/ 3
C. (SBP + 3DBP)/ 2
D. (DBP + 3SBP)/ 2
Answer: A
35. Cerebral blood flow is regulated by all except:
A. Blood pressure
B. Arterial PCO2
C. Potassium ions
D. A & C
Answer: D
36. Gastrin is produced by :
A. Pancreas
B. Gastric antral cells
C. Pituitary
D. All
Answer: D
37. Gastric secretion is :
A. Inhibited by curare
B. Stimulated by nor adrenaline
C. Increased by stomach distention
D. Stimulated by an increase in tonic activity
Answer: C
38. Which inhibits gastric secretion ?
A. Secretin
B. Insulin
C. High gastric pH
D. Calcium
Answer: A
39. Pancreatic juice rich in water and electrolytes poor in enzymes is secreted in response to :
A. Pancreatozymin
B. Cholecystokinin
C. Secretin
D. Proteins
Answer: C
40. Small intestinal peristalsis is controlled by :
A. Myentric plexus
B. Meissners plexus
C. Vagus nerve
D. Para sympathetic system
Answer: A
41. Ovarian reserve is best indicated by
A. LH
B. FSH
C. LH/ FSH ratio
D. Estrogen
Answer: B
42.Which of these is not a part of extracellular matrix:
A. Laminin
B. Fibronectin
C. Integrins
D. Collagen
Answer: C
43. All of the following occur in mitochondria except
A. Citric acid cycle (Kreb’s cycle)
B. Glycogenolysis
C. Fatty acid oxidation
D. Electron transport chain
Answer: B
44. QRS complex is due to: [September 2008]
A. Ventricular repolarization
B. Atrial depolarization
C. Conduction through AV node
D. Ventricular depolarization
Answer: D
45. Coronary blood flow is maximum during which phase of cardiac cycle:
A. Isovolumic relaxation phase
B. Isovolumic contraction phase
C. Ejection phase
D. Isovolumic contraction phase
Answer: A
46. Aortic valve closure corresponds to the beginning of: [September 2011]
A. Systole
B. Parasystole
C. Isovolumetric relaxation
D. Isovolumetric contraction
Answer: C
47. Chymotrypsinogen is activated into chymotrypsin by:
A. Trypsin
B. Pepsin
C. Renin
D. HCl
Answer: A
48. Shivering is controlled by: [September 2012, March 2013]
A. Dorsomedial nucleus
B. Posterior hypothalamus
C. Perifornical nucleus
D. Lateral hypothalamic area
Answer: B
49. Vomiting centre is situated in the: [September 2008]
A. Hypothalamus
B. Midbarin
C. Pons
D. Medulla
Answer: D
50. Bohr effect is described as: [September 2009]
A. Decrease in CO2 affinity of hemoglobin when the pH of blood rises
B. Decrease in CO2 affinity of hemoglobin when the pH of blood falls
C. Decrease in O2 affinity of hemoglobin when the pH of blood rises
D. Decrease in O2 affinity of hemoglobin when the pH of blood falls
Answer: D
51. FALSE for seminal vesicles: [September 2012]
A. Contains large amount of fructose
B. Stores sperms
C. Situated on either side near prostate
D. Secretion of seminal vesicle gives mucoid consistency to semen
Answer: B
52. Which of the following are inactive during normal respiration ?
A. Pre-Botzinger complex
B. Dorsal group of neurons
C. Ventral VRG group of neurons
D. Pneumotaxic center
Answer: C
53. Sleep centre is located in
A. Basal ganglia
B. Medulla
C. Hypothalamus
D. Cerebellum
Answer: C
54. Aromatase produces estrogen from
A. Progesterone
B. Cortisol
C. Aldosterone
D. Androgen
Answer: D
55. Action of progesterone ?
A. Increased sensitivity of uterus to oxytocin
B. Inhibits LH secretion
C. Decrease in body temperature
D. Causes proliferative changes in uterus
Answer: B
56. Corpus leuteum starts regressing after how many days of ovulation ?
A. 5 days
B. 10 days
C. 24 days
D. None
Answer: B
57. Weber Fechner law is related to ?
A. Phantom limb
B. Force of contraction in heart
C. Intensity of stimulus and sensation felt
D. Cortical plasticity
Answer: C
58. Maximum amount of K+ ion is seen in which GI secretion ?
A. Saliva
B. Colonic
C. Gastric
D. Jejunal
Answer: A
59. Blood supply of brain is ?
A. 1500 ml/min
B. 2000 ml/min
C. 750 ml/min
D. 250 ml/min
Answer: C
60. Fertilization takes place after how much time of ovulation ?
A. 1-2 days
B. 5-6 days
C. 8-12 days
D. > 12 days
Answer: A
61. Major neurotransmitter in afferents in nucleus tractus solitarius to regulate cardiovascular system ?
A. Serotoxin
B. Glutamate
C. Glycine
D. Norepinephrine
Answer: B
62. Most diffusible ion across membrane
A. Na+
B. K+
C. Cl
D. None
Answer: C
63. Cells most sensitive to hypoxia are ?
A. Myocardial cells
B. Neurons
C. Hepatocytes
D. Renal tubular epithelial cells
Answer: B
64. Beta-2 transferrin is found in ?
A. Blood
B. Urine
C. Tear
D. CSF
Answer: D
65. What will occur with increase in alveolar ventilation rate ?
A. Decreased partial pressure of O2 in alveoli
B. Decreased partial pressure of CO2 in alveoli
C. Decreased CO2 diffusion from blood to alveoli
D. Decreased O2 diffusion from alveoli to blood
Answer: B
66. Tone of lower esophageal sphincter is increased by?
A. NO
B. VIP
C. Acetylcholine
D. Epinephrine
Answer: C
67. While walking or standing, posture is maintain by ?
A. Basal ganglia
B. Hypothalamus
C. Cerebellum
D. Amygdala
Answer: C
68. Pepsinogen is activated by ?
A. Enterokinase
B. Enteropeptidase
C. H+
D. Trypsin
Answer: C
69. Bile acid has a detergent action due to ?
A. Formation of soap
B. Formation of zwitter ion
C. Amphipathic nature of bile salts
D. Formation of medium chain triglycerides
Answer: C
70. Myelination in peripheral nervous system is done by
A. Astrocytes
B. Oligodendrocytes
C. Ependymal cells
D. Schwann cells
Answer: D
71. Digestion of disaccharides occurs at ?
A. Mouth
B. Stomach
C. Small intestine
D. Large intestine
Answer: C
72. Dicrotic notch is caused by
A. Closure of mitral valve
B. Opening of mitral valve
C. Closure of aortic valve
D. Opening of aortic valve
Answer: C
73. Which of the following is an example of active transport?
A. Movement of water across cell membrane
B. Movement of oxygen across cell membrane
C. Co-transport of amino acids with sodium
D. None of the above
Answer: C
74. Chloride shift is due to ?
A. Generation of HCO-3 in RBCs
B. Metabolism of glucose in RBCs
C. Formation of O2-Hb complex in RBCs
D. None
Answer: A
75. Which of the following is passively absorbed in gut ?
A. Glucose
B. Lipids
C. Fructose
D. Amino-acids
Answer: B
76. Pulmonary vasodilatation is caused by ?
A. Hypoxia
B. Thromboxane A2
C. Histamine
D. Angiotensin-II
Answer: C
77. Life span of neonatal RBC ?
A. 60-90 days
B. 90-120 days
C. 120-150 days
D. 150-200 days
Answer: A
78. Skin blood flow is decreased by ?
A. Dopamine
B. Isoprenaline
C. Noradrenaline
D. Acetylcholine
Answer: C
79. Autophagic vacuoles fuse with ?
A. Golgi complex
B. ER
C. Lysosome
D. Mitocondria
Answer: C
80. Feed forward inhibition synapse seen in
A. Medulla
B. Cerebellum
C. Basal ganglia
D. Hypothalamus
Answer: B
81. Main enzyme involved in digestion of fatty food?
A. Lingual lipase
B. Gastric lipase
C. Pancreatic lipase
D. Phospholipase
Answer: C
82. Motor protein in organ of corti ?
A. Kinesin
B. Albumin
C. Dynein
D. Myosin
Answer: D
83. Vibrations are felt by ?
A. Meissner’s corpuscle
B. Merkel’s disc
C. Pacinian corpuscle
D. Ruffini’s end organ
Answer: C
84. Herring Breuer reflex is an increase in ?
A. Duration of inspiration
B. Duration of expiration
C. Depth of inspiration
D. Depth of expiration
Answer: B
85. Amount of gastric juice secreted per day ?
A. 500-1000 ml
B. 1000-1500 ml
C. 2000-2500 ml
D. 3000-3500 ml
Answer: C
86. True about gap junctions are all, except ?
A. Transmit electric signals
B. Allow ions to pass
C. Intercellular space 1000 nm
D. Seen in cardiac muscle
Answer: C
87. In starvation, earliest to become depleted
A. Carbohydrates
B. Proteins
C. Fats
D. None
Answer: A
88. Growth hormone secretion is stimulated by ?
A. Increased blood glucose
B. Decreased blood glucose
C. Cortisol
D. Somatostatin
Answer: B
89. Isocapnic exercise is ?
A. Breathing for short duration against resistance
B. Breathing of decreased volume of ventilation
C. Breathing of increased volume of ventilation for long period
D. Breathing of decreased volume for long period
Answer: C
90. Hormones required during puberty ?
A. LSH
B. Testesterone
C. Leptin
D. All of the above
Answer: D
91. Capacitance vessels have in their wall ?
A. More elastic tissue and less muscle
B. Less elastic tissue and more muscle
C. More elastic tissue and more muscle
D. Less elastic tissue and less muscle
Answer: D
92. Effect of cholecystokinin on GIT ?
A. Increases gastric acid secretion
B. Increases small intestinal peristlasis
C. Increases gastric motility
D. Relaxes gall bladder
Answer: B
93. Pubarche is due to ?
A. GH
B. Progesterone
C. Testosterone
D. Estrogen
Answer: C
94. False about total body water (TBW) ?
A. ICF is 2/3rd of TBW
B. In newborn TBW is 60% of body weight
C. Premature newborns have more TBW
D. In adults, TBW is 60% of body weight
Answer: B
95. Which of following is a microfilament ?
A. Tubulin
B. Actin
C. Desmin
D. Vimentin
Answer: B
96. All belong to molecular motor family except ?
A. Kinesin
B. Dynein
C. Myosin
D. Actin
Answer: D
97. Cells which surround the oocyst in graafian follicle are called ?
A. Discus proligerus
B. Cumulus oophoricus
C. Luteal cells
D. Villus cells
Answer: B
98. Following changes are seen during capacitation of a sperms except ?
A. Increased permeability to calcium
B. Decreased permeability to calcium
C. Removal of cholesterol from acrosome
D. Increased motility
Answer: B
99. Mismatch of ventilation/perfusion ratio is seen in
A. Apex
B. Base
C. Both
D. None
Answer: C
100. Carotid and aortic bodies are stimulated when ?
A. Oxygen saturation decreases below 90%
B. Oxygen saturation decreases below 80%
C. Oxygen saturation decreases below 70%
D. Oxygen saturation decreases below 60%
Answer: A
101. Sense organ which is having efferent supply
A. Golgi tendon organ
B. Organ of corti
C. Retina
D. Taste bud
Answer: B
102. False regarding papillae of tongue ?
A. Fungiform papillae at tip
B. Circumvallate papillae at base
C. Foliate papillae at back edge
D. Filiform papillae have taste buds at tip
Answer: D
103. Electric potential of resting membrane for a given electrolyte is given by which equation ?
A. Nernst
B. Goldman
C. Donnan-Gibbs
D. None
Answer: A
104. In circulatory biomechanics which of the following is true?
A. Blood viscosity is increased in anemia
B. Blood viscosity is decreased in polycythemia
C. Cardiac output is increased in anemia
D. Cardiac output is decreased in Beri-Beri
Answer: C
105. Hemoglobin binds/transports all except ?
A. CO
B. O2
C. SO2
D. CO2
Answer: C
106. Fever is produced by ?
A. PGF2α
B. PGE2
C. PGI2
D. PGD2
Answer: B
107. Normal capillar wedge pressure ?
A. 0-2 mm Hg
B. 5-10 mm Hg
C. 15-20 mm Hg
D. 20-30mm Hg
Answer: B
108. Insulin resistance down-regulates A. GLUT-1
B. GLUT-2
C. GLUT-3
D. GLUT-4
Answer: D
109. Plateau of oxygen-haemoglobin dissociation curve signifies ?
A. No oxygen is available for binding to Hb
B. No Hb molecule is available to bind with O2
C. All oxygen is released to tissues
D. None of the above
Answer: B
110. Which of the following increases appetite ?
A. CART
B. α – MSH
C. AGPP
D. Insulin
Answer: C
11. True about iron absorption are all, except ?
A. Major site of absorption is duodenum
B. Stored as Ferritin
C. Absorbed in ferrous form
D. Pancreatic secretions improves the absorption
Answer: D
112. Cardiac output increases by ?
A. Standing from lying down position
B. Expiration
C. Increased cardiac contractility
D. Parasympathetic stimulation
Answer: C
113. Spermatogenesis takes place in ?
A. Epididymis
B. Seminiferous tubule
C. Ductus deferens
D. Prostate
Answer: B
114. Estrogen Beta receptors are found on
A. Uterus
B. Blood vessels
C. Ovary
D. Vagina
Answer: C
115. Endogenous pyrogens act by ?
A. Increasing heat generation
B. Raising thermostat point of hypothalamus
C. Causing vasoconstriction
D. By Non-shivering thermogenesis
Answer: B
116. Extrinsic system of coagulation is activated by
A. Factor XI
B. Factor X
C. Factor XII
D. Factor III
Answer: D
117. Sharp pain is transmitted by which type of fibres?
A. Aα
B. Aβ
C. Aδ
D. C
Answer: C
118. Reward center is located in ?
A. Cerebellum
B. Amygdala
C. Hippocampus
D. Hypothalamus
Answer: D
119. Correct order of velocity ?
A. Vena cava > Aorta > Vein > Artery > Venule > Arteriole
B. Aorta > Vena cava > Artery > Vein > Arteriole > Venule
C. Aorta > Artery > Vena cava > Vein > Arteriole > Venule
D. Vena cava > Vein > Aorta > Artery > Venule > Arteriole
Answer: B
120. Maximum water reabsorption in the Gastrointestinal tract occurs in ?
A. Stomach
B. Jejunum
C. Ileum
D. Colon
Answer: B
121. Thyroid gland is stimulated by which hormone during pregnancy ?
A. Prolactin
B. HCG
C. Human placental lactogen
D. ACTH
Answer: B
122. FSH and LH both are inhibited by ?
A. Cortisol
B. Aldosterone
C. Estrogen
D. Progesterone
Answer: C
123. Gamma glutamate carboxypeptidase is linked with absorption of ?
A. Riboflavin
B. Niacin
C. Folic acid
D. Pyridoxinel
Answer: C
124. The oxygen dissociation curve of myoglobin & haemoglobin is different due to?
A. Hb can bind to 2 oxygen molecules
B. Cooperative binding in Hb
C. Myoglobin has little oxygen affinity
D. Haemoglobin follows a hyperbolic curve
Answer: B
125. Myosin and actin filaments are kept in place by
A. Tropomyosin
B. Troponin
C. Actinin
D. Titin
Answer: D
126. True about cerebellar neuronal connections ?
A. Climbing fibres from inferior olivary nucleus
B. Mossy fibres from inferior olivary nucleus
C. Climbing fibres are inhibitory to Purkinje cells
D. Mossy fibres are inhibitory to Purkinje cells
Answer: A
127. Lifespan of fetal RBC is ?
A. Same as adult RBC
B. 1/4 of adult RBC
C. 1/2 of adult RBC
D. 2/3 of adult RBC
Answer: D
128. Baroreceptor are ?
A. Carotid body
B. Carotid sinus
C. Aortic body
D. None
Answer: B
129. Insulin secretion is normally stimulated by ?
A. GLP-1
B. GLP-2
C. VIP
D. α-adrenergic receptors
Answer: A
130. Insulin mediated glucose transport is seen in ?
A. Adipose tissue
B. Brain
C. RBC
D. Kidney
Answer: A
131. Increased BMR is associated with ?
A. Increased body fat store
B. Increased glycognenesis
C. Increased glycolysis
D. Increased lipogenesis
Answer: C
132. Post-tetanic potentiation is due to
A. Hyperpolarization of muscle fibres
B. Rapid K+ efflux
C. Increased availability of Ca++
D. Rapid Na+ influx
Answer: C
133. Which of the following has small representation in somatosensory area of cerebral cortex ?
A. Lips
B. Thumb/fingers
C. Tongue
D. Trunk
Answer: D
134. Factor X is ?
A. Hageman factor
B. Stuart-Prower factor
C. Christmas factor
D. Tissue factor
Answer: B
135. Resting membrane potential in cardiac muscle ?
A. -70 mV
B. +70 mV
C. -90 mV
D. +90 mV
Answer: C
136. Effect of GLP-1 ?
A. Increased aldosterone secretion by adrenal
B. Increased PTH secretion
C. Increased insulin secretion from beta-cells of pancreas
D. Increased testosterone secretion from Leydig cells
Answer: C
137. Noradrenaline is major neurotransmitter in ?
A. Postganglionic parasympathetic fibres
B. Postganglionic sympathetic fibres except in sweat glands
C. Autonomic ganglia
D. Preganglionic autonomic fibres
Answer: B
138. Gamma globulin are synthesized in ?
A. Liver
B. Spleen
C. Kidney
D. Plasma cells
Answer: D
139. Normal cerebral blood flow in ml/min ?
A. 55
B. 150
C. 750
D. 1000
Answer: C
140. Role of growth hormone in spermatogenesis ?
A. Late division of spermatocytes
B. Early division of spermatogonia
C. Formation of Acrosomes
D. Stimulation of sertoli and Leydig cells
Answer: B
141. Growth hormone has its effect on growth through?
A. Directly
B. IG1-1
C. Thyroxine
D. Intranuclear receptors
Answer: B
142. Growth hormone does not cause ?
A. Gigantism
B. Acromegaly
C. Diabetes mellitus
D. Hypothyroidism
Answer: D
143. Migrating motor complex is due to which GI hormone ?
A. Gastrin
B. Motilin
C. CCK
D. VIP
Answer: B
144. Sensations which are appreciated in thalamus
A. Proprioception
B. Pain & temperature
C. Tactile sensations
D. Pressure
Answer: B
145. NO acts on platelets through ?
A. cAMP
B. Adenosine
C. cGMP
D. TX-A2
Answer: C
146. Mitral and periglomerular cells are seen in ?
A. Medulla
B. Olfactory bulb
C. Primary visual cortex
D. Geniculate body
Answer: B
147. Derivative of POMC
A. Norepinephrine
B. Dopamine
C. ACTH
D. Acetylcholine
Answer: C
148. Preaccelerin is ?
A. Eater II
B. Facter V
C. Facter VII
D. Facter X
Answer: C
149. Which of the following is not an intermediate filament?
A. Keratin
B. Desmin
C. Tubulin
D. Lamin
Answer: C
150. Antimullerian hormone is secreted by ?
A. Granulosa cells
B. Lyedig cells
C. Sertoli cells
D. None
Answer: C
151. Hepcidin inhibits ?
A. Absorption of cobalamine
B. Transfer of iron into enterocytes
C. Folic acid synthesis
D. Respiratory oxidase
Answer: B
152. Stroke volume is increased by ?
A. Increased end-diastolic and end-systolic volumes
B. Decreased end-diastolic and end-systolic volumes
C. Increased end-diastolic volume and decreased end-systolic volume
D. Decrased end-diastolic volume and increased end-systolic volume
Answer: C
153. Effect of infusion of hypotonic saline?
A. Increased ICF only
B. Increased ECF only
C. Increased in both ICF and ECF
D. Increased ICF and decreased ECF
Answer: C
154. Smooth muscle physiology different from skeletal muscle
A. K+ requires for contraction
B. Ca2+ required for contraction
C. Troponin is absent
D. Myosin is required for contraction
Answer: C
155. Normal respiratory compliance is ?
A. 200 ml/cm water
B. 50 ml/cm water
C. 100 ml/cm water
D. 150 ml/cm water
Answer: A
156. Cushing reflex is associated with all except ?
A. Hypotension
B. Increased intracranial pressure
C. Bradycardia
D. Tachyponea
Answer: A
157. Which of the following technique is used to study current flow across a single ion channel?
A. Patch clamp
B. Voltage clamp
C. lontophoresis
D. Galvanometry
Answer: A
158. Poiseuille’s equation states that
A. Blood flow is directly proportion to 2nd power of radius
B. Blood flow is directly proportion to 4th power of radius
C. Blood flow is inversely proportion to 2nd power of radius
D. Blood flow is inversely proportion to 4th power of radius
Answer: B
159. True about calcium reabsorption in the kidney?
A. Most of the calcium reabsorption occurs in DCT
B. Major regulating factor is Parathormone
C. Parathormone decreases calcium reabsorption
D. Increased plasma phosphate decreases calcium reabsorption
Answer: B
160. Which carrier pump is transporting solutes in thick ascending limb of Henle loop?
A. Carrier pump Na-K-2Cl transporter.
B. NaCl- cotransporter
C. Na2+-H+ exchanger
D. Na2+-K+ exchanger
Answer: A
161. What is the partial pressure for oxygen in the inspired air?
A. 116 mm Hg
B. 158 mm Hg
C. 100 mm Hg
D. 0.3 mm Hg
Answer: B
162. What are the cellular contents of cerebellar cortex?
A. Cortical cells
B. Glomus cells
C. Principle cells
D. Intercalated cells
Answer: A
163. Which cells are referred as “Pacemaker cells” with relation to ‘BER’?
A. SA node
B. AV node
C. Interstitial cells of Cajal.
D. Pyramidal cells
Answer: C
164. Testosterone secreted by,
A. Leydig’s cells.
B. Somatotropic cells.
C. Acidophilic cells.
D. Gonadotropic cells
Answer: A
165. Vasopressin acts through which channels in collecting duct?
A. Aquaporin 1
B. Aquaporin 2
C. GLUT –
D. GLUT – 4
Answer: B
166. True about decorticate rigidity?
A. Removal of cerebral cortex and basal ganglia
B. Flexion of lower limbs & extension of upper limbs
C. Rigidity is less pronounced than decerebrate rigidity
D. None of the above
Answer: C
167. Bainbridge reflux causes?
A. Bradycardia
B. Increased cardiac output
C. Decreased venous return
D. Increased heart rate
Answer: D
168. Golgi tendon organ responsible for?
A. Tension
B. Length
C. Pressure
D. Proprioception
Answer: A
169. Hormone predominately secreted after 14 day on endometrium is?
A. Progesterone
B. Estrogen
C. LH
D. FSH
Answer: A
170. Peripheral chemoreceptors respond to hypoxia using which channel?
A. Calcium channel
B. Sodium channel
C. Potassium channel
D. Chloride channel
Answer: C
171. With increase in age which of the following is true for lungs?
A. Pulmonary compliance increases
B. Residual volume decreases
C. Mucocillary clearance increases
D. Fibrous of interstitium dreaseses
Answer: A
172. Functional residual volume is?
A. After normal inspiration
B. After normal expiration
C. After forceful expiration
D. After forceful inspiration
Answer: A
173. Polyuria is
A. 70ml/kg
B. 60ml/kg
C. 50ml/kg
D. 40ml/kg
Answer: C
174. Tubuloglomerular feedback control is useful for which one of the following?
A. GFR
B. Plasma sodium
C. Plasma volume
D. Determining tubular secretion
Answer: A
175. Calcitonin levels increased in
A. Hyperthyroidism
B. Hyperparathyroidism
C. Hypoparathyroidism
D. Cushing Syndrome
Answer: B
176. When the values of Fev1=1.3 & FCV=3.9. Which of the following does this signify?
A. Normal lung function
B. Obstructive lung disease
C. Restrictive lung disease
D. Both
Answer: B
177. Antegrade peristalsis due to?
A. Ach
B. Serotonin
C. Substance P
D. VIP
Answer: D
178. C-peptide seen in?
A. In Pre-proinsulin
B. In Proinsulin
C. As a combined entity with insulin after secretion
D. A gastrointestinal proactive molecul
Answer: B
179. In forceful expiration, which of the following neurons gets fired?
A. VRG
B. DRG
C. Pneumotaxic centre
D. Chemoreceptors
Answer: A
180. Slow conduction velocity is seen with which of the following nerve fibers?
A. Preganglionic autonomic nerve fibers
B. Postganglionic autonomic nerve fibers
C. Motor nerves
D. Sympathetic nerve fibers
Answer: B
181. Calculate the ejection fraction from the given volume pressure curve:
A. 40%
B. 50%
C. 55%
D. 60%
Answer: D
182. Chemoreceptors are located in which area?
A. Medulla
B. Arch of aorta
C. Bifurcation of carotid artery
D. All of the above
Answer: D
183. Hormone responsible for BP regulation after a fall due to blood loss.
A. ADH
B. ANP
C. Epinephrine
D. Aldosterone
Answer: A
184.Sodium channels are maximum in which part of neuron ?
A. Soma
B. Axon hillock
C. Dendrites
D. Axon
Answer: B
185. Blood supply of liver [m1/100g/min]
A. 1500-2000
B. 1000-1500
C. 50-60
D. 250-300
Answer: C
186. Conversion of prekallikrein to kallikrein requires which clotting factor A. XIII
B. XII
C. XI
D. X
Answer: B
187. The only excitatory neurons in cerebellar cortex are?
A. Purkinje
B. Basket
C. Golgi
D. Granule cells
Answer: D
188. Temperature centre is ?
A. Supraoptic nucleus of hypothalamus
B. Paraventricular nucleus of hypothalamus
C. Preoptic nucleus of hypothalamus
D. Suprachiasmatic nucleus of hypothalamus
Answer: C
189. Righting reflex is a ?
A. Cochlear reflex
B. Spinal reflex
C. Vestibular reflex
D. None of the above
Answer: C
190. Biphasic action potential of mixed nerve except?
A. All or none phenomenon
B. Two or more positive peaks
C. Refractory period
D. Recorded on surface
Answer: B
191.Which of the following is/are effect of increased 2,3-DPG on oxygen haemoglobin dissociation curve?
A. ↑ ed affinity of haemoglobin to oxygen
B. ↓ ed affinity of haemoglobin to oxygen
C. Left shift of oxygen-hemoglobin dissociation curve
D. Right shift of oxygen-hemoglobin dissociation curve
E. No change in oxygen-hemoglobin dissociation curve
Answer: B😀
192. True statement relating to compliance of lung:
A. Increased by surfactant
B. Decreased in emphysema
C. At height of inspiration compliance is less
D. It can be measured by measuring intrapleural pressure at different lung volume
E. None
Answer: A:C:D
193. Lipid rafts are seen in?
A. Ribosomes
B. Mitochondria
C. Plasma membrane
D. ER
Answer: C
194. Marker of endoplasmic reticulum?
A. Acid phosphatase
B. Glucose-6-phosphatase
C. Catalase
D. LDH
Answer: B
195. Following is a feature of simple diffusion?
A. Against a concentration gradient
B. Easy for non-polar substance
C. More in thick membrane
D. Requires carrier protein
Answer: B
196. Most common mechanism for transport into the cell?
A. Diffusion
B. Primary active transport
C. Antiport
D. Cotransport
Answer: A
197. True about Nernst equation?
A. Used to calculate equilibrium potential
B. Calculated for non-ionic solution
C. Nernst potential for Cl is -90 my
D. All are correct
Answer: A
198. Actin is which type of protein?
A. Fibrous
B. Globular
C. Both
D. None
Answer: C
199. Somatic efferent of which arise from medulla?
A. Oculomotor
B. Trochlear
C. Abducent
D. Hypoglossal
Answer: D
200. Third order neurons of sensations from face arise in?
A. Medulla
B. Spinal nucleus of trigeminal
C. Thalamus
D. Brainstem
Answer: C
201. ECF concentration of 1C. is 150 meq/L and ICF concentration of le is 5 meq/L. What is the equilibrium potential for K+ is?
A. +60 mV
B. -60 mV
C. -90 mV
D. +90 mV
Answer: C
202. True about heterophilic receptors?
A. Involved in binding of GH to cell membrane
B. Bind to same ligand/hormone
C. Involved in cell adhesion
D. All are correct
Answer: C
203. Nernnst equation related to equilibrium potential does not depend upon?
A. Concentration gradient
B. Electric gradient
C. Non-ionic solution
D. Concentration of ions in two solution
Answer: C
204. Due to Donnan-Gibbs effect?
A. Concentration of K. is greater in ECF
B. Concentration of cl is greater in ECF
C. Total ions are more in ICF
D. All are true
Answer: C
205. ATPase is which type of pump?
A. Secondary active
B. Electrogenic
C. Symport
D. All of the above
Answer: B
206. Diffusion related to 02 transport across respiratory membrane is an example of?
A. Simple diffusion
B. Facilitated diffusion
C. Active diffusion
D. Osmotic diffusion
Answer: A
207. Apnea-hypopnea index is used for?
A. Emphysema
B. Asthma
C. Hyaline membrane disease
D. Obstructive sleep apnea [OSAI
Answer: D
208. Measurement of intracellular fluid in a 50 years old male is done by?
A. Dilution method
B. Evans blue
C. D20
D. Indirectly
Answer: D
209. Calculation of interstitial fluid in a 50 years old is done by?
A. TBW minus ECF
B. ECF minus plasma volume
C. ICF minus ECF
D. TBW minus ICF
Answer: B
210. Hypercoagulable factor is?
A. Protein C
B. Protein S
C. Factor V Leiden
D. Antithrombin III
Answer: C
211. Excitability of cells is maximally affected by change in concentration of which ion?
A. IC+
B. Na*
C. a
d) Ca+2
Answer: D
212. Inhibition of Na* ATPase leads to?
A. Decreased Na* in the cell
B. Increased Ca’ in the cell
C. Increased K* in the cell
D. Increased Cl- in the cell
Answer: B
213. Non-specific pain pathway is for?
A. Nociceptive pain
B. Neuropathic pain
C. Idiopathic pain
D. Inflammatory pain
Answer: C
214. Shortest phase of sexual cycle?
A. Excitement phase
B. Plateu phase
C. Orgasmic phase
D. Resolution
Answer: C
215. Dull visceral pain is carried by which type of neurons?
A. A gamma
B. Aa
C. C fibres
D. B
Answer: C
216. Erection of penis occurs in which phase of sexual cycle?
A. Excitement phase
B. Plateu phase
C. Orgasmic phase
D. Resolution
Answer: A
217. ‘C’ fibers carry sensations through which pathway?
A. Posterior column
B. Anterior spinothalamic tract
C. Lateral spinothalamic tract
D. All of the above
Answer: C
218. Premature ejaculation occurs in which phase of sexual cycle?
A. Excitement phase
B. Plateu phase
C. Orgasmic phase
D. Resolution
Answer: C
219. Types C nerve fibers are?
A. Sensory
B. Motor
C. Mixed
D. Any of the above
Answer: A
220. Exercise mediated increase in muscular blood flow is mediated by which sympathetic fibers
A. Adrenergic
B. Noradrenergic
C. Dopaminergic
D. Cholinergic
Answer: D
221.Phosphate/phosphorus is present in which part of cell?
A. Cell membrane
B. DNA
C. RNA
D. All of the above
Answer: D
222. Warmth sensation is carried by?
A. A a fibers
B. A (3 fibers
C. A y fibers
D. A S fibers
Answer: A
223. True about myosin?
A. Thin filament
B. Covers active site of action
C. Has ATPase activity
D. Ca’ binding protein
Answer: C
224.Maximum storage of magnesium occurs in which part of body?
A. Adipose tissue
B. Skeletal muscles
C. Blood
D. Bone
Answer: D
225. In cardiac muscles, T-tubules are present at?
A. Z lines
B. A lines
C. I lines
D. A-I junction
Answer: A
226. Tisse factor activates?
A. Preaccelerin
B. Hageman facter
C. Labile facter
D. Prothrombin
Answer: A
227. Tissue factor activates?
A. Intrinsic pathway
B. Contact pathway
C. In vitro pathway
D. In vivo pathway
Answer: D
228. In a muscle fiber at rest, the length of the I band is 1 mm and A band is 1.5 mm. What is the length of the sarcomere
A. 0.5 mm
B. 2.5 mm
C. 3 5 mm
D. 5 mm
Answer: B
229. Hormone which affects IC* ion concentration?
A. GH
B. Thyroxine
C. Insulin
D. Estrogen
Answer: C
230. White fibers are present in which muscle?
A. Calf muscles
B. Back muscles
C. Gluteal muscles
D. Hand muscles
Answer: D
231. Function of muscle spindle is?
A. Movement of a limb
B. Muscle tone maintenance
C. Goal oriented muscle contraction
D. All of the above
Answer: B
232. Afferents for stretch reflexes are carried by which fibers?
A. Aa
B. Ay
C. Type B
D. Type C
Answer: A
233. All are true regarding intracellular receptors, except?
A. Act by regulating gene expression
B. Fastest acting receptors
C. Glucocorticoid receptors
D. DNA contains hormone responsive elements
Answer: B
234. Spinal cord has how many synapses in golgi tendon reflex?
A. 1
B. 2
C. 3
D. 4
Answer: B
235. Secretion of cortisol is highest at?
A. Mid-night
B. Early morning
C. Afternoon
D. Evening
Answer: B
236. Inverse stretch reflex is a?
A. Monosynaptic reflex
B. Bisynaptic reflex
C. Polysynaptic reflex
D. Nonsynaptic reflex
Answer: B
237. True about ACTH and cortisol [corticosteroid] secretion?
A. Maximum secretion in the evening
B. ACTH has negative feed-back control
C. ACTH has major effect on mineralocorticoid secretion
D. ACTH is derived from POMC
Answer: B😀
238. Facilitatory presynaptic neurotransmitter is?
A. GABA
B. Glycine
C. Glutamate
D. Aspartate
Answer: C😀
239. Gene for insulin responsive glucose transporter is located on chromosome?
A. 7
B. 21
C. 17
D. 13
Answer: C
240. Glucose transporter affected in diabetes mellitus?
A. GLUT-2
B. GLUT-5
C. GLUT-4
D. SGLT-2
Answer: C
241.Nissl’s granules are found in which part of nerve cell
A. Axon hillock
B. Axons
C. Node of Ranvier
D. Body
Answer: D
242. Stereocilia are found in?
A. Eye
B. Nose
C. Tongue
D. Epididymis
Answer: D
243. Mechanism of action of 5-a reductase?
A. Breakage of C4C5 double bond
B. Breakage of C-N bond
C. Breakage of amide bond
D. Breakage of N-N bond
Answer: A
244. Stereocilia are present in?
A. Taste buds
B. Hair cells
C. Retina
D. Nose
Answer: B
245. CSF pressure is increased in all except
A. Forced inspiration
B. Coughing
C. Valsalva manoeuvre
D. Crying
Answer: A
246. cAMP activates?
A. Protein kinase ‘A’
B. Protein kinase ‘C’
C. Nuclear transcription
D. Phospholipare
Answer: A
247. CSF is present in which space?
A. Central canal of spinal cord
B. Ventricles of brain
C. Subarachnoid space
D. All of the above
Answer: D
248. Maximum daily degradation of haemoglobin in normal adults?
A. 2 gm
B. 4 gm
C. 6 gm
D. 8 gm
Answer: D
249. Daily fecal urobilinogen excretion in healthy adults?
A. 20-40 gm
B. 40-280 gm
C. 20-40 mg
D. 40-280 mg
Answer: D
250. Function of Ghrelin?
A. Stimulate water absorption
B. Increase appatite
C. Regulation of temperature
D. Stimulate lipogenesis
Answer: B
251. Location of visual cortex?
A. Precentral gyrus
B. Postcentral gyrus
C. Sylvian fissure
D. Calcarine sulcus
Answer: D
252. Parvocellular pathway for vision is concerned with?
A. Fine details of object
B. Movements of object
C. Flickering features
D. Depth of vision
Answer: A
253. Sweat glands are supplied by all except?
A. Cholinergic neurons
B. Sympathetic neurons
C. Adrenergic neurons
D. C-fibers
Answer: C
254. Gustatory pathway involves which nerve?
A. Facial
B. Glossopharyngeal
C. Vagus
D. All of the above
Answer: D
255. True about basic rhythm of GIT?
A. Fluctuate between -65 and -40 mV
B. Initiated by zymogen cells
C. Pacemaker cells are present in proximal stomach
D. All of the above
Answer: A
