1. Major apolipoprotein of chylomicrons ?
A. B-100
B. D
C. B-48
D. None
Answer: C
2. True about Glutathione except ?
A. Tripeptide
B. Formed from glutamic acid, glycine, cysteine
C. Act as antioxidant in reduced state
D. All of the above
Answer: D
3. Concentration of which is inversely related to the risk of coronary heart disease ?
A. VLDL
B. LDL
C. HDL
D. None
Answer: C
4. Maximum cholesterol is seen in ?
A. VLDL
B. LDL
C. HDL
D. Chylomicrons
Answer: B
5. In humans, end product of purine metabolism
A. Allantoin
B. Uric acid
C. CO2
D. None
Answer: B
6. All are true about chaperones except ?
A. Cause folding of proteins
B. Are lipid in nature
C. May have ATPase activity
D. Include heat shock proteins
Answer: B
7. Which Vitamin is involved in Redox reactions
A. Pyridoxin
B. Biotin
C. Folic acid
D. Riboflavin
Answer: D
8. Ninhydrin test is used for ?
A. Bile salts
B. Amino acids
C. Nucleic acid
D. Lipids
Answer: B
9. Which is not a dietary fiber ?
A. Lignin
B. Lactulose
C. Pectin
D. Cellulose
Answer: B
10. ATP is generated in ETC by ?
A. Na’ ATPase
B. Cl- ATPase
C. FoF, ATPase
D. ADP Kinase
Answer: C
11. Atractiloside act as ?
A. Uncoupler
B. Inhibitor of oxidative phosphorylation
C. Inhibitor of complex I of ETC
D. Inhibitor of complex III of ETC
Answer: B
12. Riboflavin is a constituent of ?
A. FMN
B. NAD
C. PLP
D. THF
Answer: A
.
13. Rate limiting step in pyrimidine synthesis ?
A. Dihydro-orotase
B. Ornithine transcarbomoylase
C. Aspartate transcarbomoylase
D. Carbamoyl phosphate synthase-I
Answer: C
14. All are characteristics of genetic code ?
A. Overlapping
B. Nonambiguous
C. Universal
D. Degeneracy
Answer: A
15. Which of the following is an example of Trinucleotide repeat mutation ?
A. Huntington’s chorea
B. Fragile-X-syndrome
C. Friedreich ataxia
D. All of the above
Answer: D
16. Which of the following is the major proteoglycan of synovial fluid ?
A. Chondroitin sulfate
B. Dermatan sulfate
C. Heparan sulfate
D. Hyaluronic acid
Answer: D
17. The main function of Vitamin C in the body is
A. Coenzyme for energy metabolism
B. Regulation of lipid synthesis
C. Involvement as antioxidant
D. Inhibition of cell growth
Answer: C
18. Enzyme specificity is given by ?
A. Km
B. Vrm„
C. Both
D. None
Answer: A
19. Natural uncoupler is ?
A. Thermogonin
B. 2, 4 nitrophenol
C. 2, 4 Dinitrophenol
D. Oligomycin
Answer: A
20. Lipid with highest mobility is ?
A. HDL
B. LDL
C. VLDL
D. Chylomicrons
Answer: A
21. Apolipoprotein E is rich in ?
A. Lysine
B. Arginine
C. Histidine
D. Methionine
Answer: B
22. Which energy molecule gives 10.5 kcal/ molecule?
A. ATP
B. GTP
C. Creatine phosphate
D. Glucose-6-phosphate
Answer: C
23. Branching enzyme is found in ?
A. Glycogenesis
B. Glucogenesis
C. Glycogenolysis
D. Glycolysis
Answer: A
24. Which of the following is not a phospholipid ?
A. Lecithine
B. Plasmalogen
C. Cardiolipin
D. Ganglioside
Answer: D
25. The mechanism by which mercury causes damage ?
A. Binds to -SH group of enzyme
B. Directly toxic
C. Inhibits ETC
D. Inhibits protein synthesis
Answer: A
26. Q10 in enzyme matches with ?
A. 2
B. 4
C. 8
D. 10
Answer: A
27. Creatine is made up of all, except ?
A. Glycine
B. Alanine
C. Methionine
D. Arginine
Answer: B
28. In urea cycle which defect is an X linkeddisease ?
A. Ornithine transcarbamylase
B. Aspartate transcarbamylase
C. Arginase
D. Argininosuccinate synthase
Answer: A
29. True regarding collagen synthesis is all except ?
A. Synthesized in ribosomes as preprocollagen
B. Hydroxylation of proline occurs in Golgi apparatus
C. Hydroxylation of lysine occurs in ER
D. Triple helix assembly occurs in ER
Answer: B
30. Type of collagen found in space of Disse in liver is
A. Collagen I & II
B. Collagen III & IV
C. Collagen II &
D. Collagen II & V
Answer: B
31. Which is predominant in normal healthyhuman ?
A. LDH 1
B. LDH2
C. LDH 3
D. LDH4
Answer: B
32. Physiological uncoupler is ?
A. Thyroxine
B. Free fatty acids
C. Thermogenin
D. All of the above
Answer: D
33. Which of the following is Aldosugar ?
A. Fructose
B. Erythrulose
C. Glucose
D. None
Answer: C
34. Key enzyme of gluconeogenesis are all except?
A. Pyruvate carboxylase
B. PEP carboxykinase
C. Pyruvate kinase
D. Glucose-6-phosphatase
Answer: C
35. Fructose intolerance is due to deficiency of ?
A. Aldolase B
B. Fructokinas
C. Triokinas
D. Aldolase A
Answer: A
36. What is essential for transfer of fatty acid across mitochondrial membrane
A. Creatine
B. Creatinine
C. Carnitine
D. None
Answer: C
37. Hexokinase is ?
A. Ligase
B. Transferase
C. Oxidoreductase
D. Reductase
Answer: B
38. Ketone body formation without glycosuria is seen in ?
A. Diabetes mellitus
B. Diabetes insipidus
C. Starvation
D. Obesity
Answer: C
39. Amino acid with double chiral is ?
A. Phenyalanine
B. Threonine
C. Tryptophane
D. Tyrosine
Answer: B
40. At physiological pH DNA is ?
A. Acidic
B. Negatively charged
C. Amphipathic
D. All of the above
Answer: D
41. Source of ammonia in urine ?
A. Glutaminase
B. Urease
C. Glutamate dehydrogenase
D. Arginase
Answer: A
42. Albumin binds with all except ?
A. Steroid
B. Calcium
C. FFA
D. Thyroxine
Answer: D
43. Chemical process involved in conversion of progesterone to glucocorticoids is
A. Methylation
B. Hydroxylation
C. Carboxylation
D. None
Answer: B
44. Gluconeogenesis occurs in all except ?
A. Liver
B. Kidney
C. Gut
D. Muscle
Answer: D
45. GLUT 2 receptors ?
A. Insulin dependent
B. Insulin independent
C. Found in cardiac muscle
D. Found in brain
Answer: B
46. Which of the following has antioxidant property?
A. Selenium
B. Copper
C. Zinc
D. All
Answer: D
47. The number of ATPs generated in krebs cycleare ?
A. 12
B. 24
C. 15
D. 30
Answer: B
48. One Krebs cycle generates how many ATP ?
A. 6
B. 12
C. 24
D. 36
Answer: B
49. Glutathione requires which vitamin to act as antioxidant ?
A. Vitamin E
B. Niacin
C. Vitamin C
D. Vitamin A
Answer: B
50. Metabolic change seen in starvation are all except?
A. Increased gluconeogenesis
B. Increased glycolysis
C. Ketogenesis
D. Protien degradation
Answer: B
51. Catecholamines are synthesized from ?
A. Tryptophan
B. Tyrosine
C. Methionine
D. Histidine
Answer: B
52. Which of the enzyme of glycolysis is a part of gluconeogenesis ?
A. Pyruvate kinase
B. PFK
C. Hexokinase
D. Phosphoglycerate kinase
Answer: D
53. Molecular interaction, found in the structure of DNA
A. Hydrogen bond
B. Glycosidic bond
C. Covalent interactions
D. All of the above
Answer: D
54. Pyridoxine is used in treatment of ?
A. Galactosemia
B. Phenylketonuria
C. Propionic acidemia
D. Homocystinuria
Answer: D
55. Membrane proteins are synthesized in ?
A. Free ribosome
B. Bound ribosome
C. Nucleolus
D. Mitochondria
Answer: B
56. Transamination of Aspartate forms ?
A. Pyruvate
B. Acetly-CoA
C. Oxaloacetate
D. Alanine
Answer: C
57. Interaction involved in primary structure of protein ?
A. Hydrogen bond
B. Disulfide bond
C. Peptide bond
D. Electrostatic bond
Answer: C
58. All are true about vitamin E except ?
A. Act as antioxidant
B. Prevent lipid peroxidation of cell membrane
C. Water soluble vitamin
D. Chemically tocopheral
Answer: C
59. Blood form of folic acid is
A. Folinic acid
B. Pteroglutamate
C. Methyl THE
D. None
Answer: C
60. Primary hypercholesterolemia is ?
A. Type I
B. Type Ha
C. Type IIb
D. Type III
Answer: B
61. Salvage purine synthesis refers to ?
A. Synthesis of purine from ribose-5-phosphate
B. Synthesis of purine from pyrimidine
C. Synthesis of purine nucleotides from purine bases
D. None of the above
Answer: C
62. RNA which contains codon for specific amino acid ?
A. tRNA
B. rRNA
C. mRNA
D. None
Answer: C
63. Glycine is required in formation of all except ?
A. Heme
B. Purines
C. Glutathione
D. Thyroxine
Answer: D
64. True about glycolysis are all except ?
A. Provide nutrition to cancer cells
B. Substrate level phosphorylation at pyruvate kinase
C. Two carbon end product is formed
D. NADPH is formed by glyceraldhyde-3-phosphate
dehydrogenase
Answer: C
65. Instant energy to muscle is provided by which pathway?
A. HMP shunt
B. Embden Meyerhof pathway
C. Cori cycle
D. TCA cycle
Answer: B
265. Which steroid is formed from cholesterol without hydroxylation ?
A. Progesterone
B. Glucocorticoid
C. Mineralocorticoid
D. Estradiol
Answer: A
66. Not obtained from plant source ?
A. Cobalamine
B. Riboflavin
C. Thiamine
D. Vitamin A
Answer: A
67. Pseudouridine found in?
A. DNA
B. rRNA
C. mRNA
D. tRNA
Answer: D
.
68. Fatty acids used by all except ?
A. Liver
B. Muscle
C. Brain
D. Kidney
Answer: C
69. Vitamin not required in TCA cycle ?
A. Niacin
B. Riboflavin
C. Thiamine
D. Folic acid
Answer: D
70. Uric acid is formed by ?
A. Catabolism of proteins
B. Catabolism of ketones
C. Catabolism of purines
D. Catabolism fo pyrimidines
Answer: C
71. Anaerobic glycolysis occurs in all places except
A. Muscles
B. RBCs
C. Brain
D. Kidney
Answer: C
72. Sweaty feet odor in urine is seen in ?
A. Phenylketonuria
B. Maple syrup urine
C. Isovaleric acidemia
D. Alkaptonuria
Answer: C
73. Ketone bodies are not used by ?
A. Muscle
B. Brain
C. RBC
D. Renal cortex
Answer: C
74. Which collagen produces sheets ?
A. I
B. II
C. IV
D. VI
Answer: C
75. The energy for glycogenesis is provided by
A. GTP
B. GDP
C. UTP
D. AMP
Answer: C
76. The function of vitamin K largely depends on which mineral ?
A. Selenium
B. Calcium
C. Iron
D. Magnesium
Answer: B
77. Amino acid with aliphatic side chain is?
A. Serine
B. Leucine
C. Threonine
D. Aspartate
Answer: B
78. According to IUB system, hydrolases belong to which class ?
A. EC-1
B. EC-2
C. EC-3
D. EC-4
Answer: C
79. Which of the following is serine protease ?
A. Pepsin
B. Trypsin
C. Carboxypeptidase
D. None
Answer: B
80. Reducing equivalants produced in glycolysis are transported from cytosol to mitochondria by ?
A. Carnitine
B. Creatine
C. Malate shuttle
D. Glutamate shuttle
Answer: C
81. HMP shunt occurs in all organs except ?
A. Liver
B. Adipose tissue
C. RBC
D. Brain
Answer: D
82. Fastest acting enzyme ?
A. LDH
B. Trypsin
C. Catalase
D. None
Answer: C
83. Inhibition of glycolysis by increased supply of 02 is called ?
A. Crabtree effect
B. Pasteur effect
C. Lewis effect
D. None
Answer: B
84. RNA is present in ?
A. Cytoplasm
B. Nucleus
C. Ribosome
D. All of the above
Answer: D
85. All are reducing sugars except
A. Sucrose
B. Lactose
C. Glucose
D. Fructose
Answer: A
86. Reducing sugar in urine can be detected by
A. Benedicts test
B. Fehling solution
C. Glucose-oxidase test
D. All of the above
Answer: D
87. Substrate level phosphorylation is by
A. Pyruvate kinase
B. Phosphofructokinase
C. Hexokinase
D. ATP synthase
Answer: A
88. Type VI glycogen storage disease is due to the deficiency of –
A. Muscle phosphorylase
B. Glucose-6-phosphatase
C. Liver phosphorylase
D. Branching enzyme
Answer: C
89. Xanthoproteic reaction involves
A. Carbolic acid
B. H2SO4
C. HCL
D. Nitric acid
Answer: D
90. Coenzyme not required in formation of glutamate
A. Thiamine pyrophosphate
B. Pyridoxial phosphate
C. Niacin
D. None of the above
Answer: A
91. Zewellger syndrone is due to absence of
A. Lysosomal
B. Mitochondria
C. Peroxisome
D. Nucleus
Answer: C
92. Urea, creatinine, nitric oxide formed by which amino acid
A. Histidine
B. Glycine
C. Cysteine
D. Arginine
Answer: D
93. Which of the following is not the source of cytosolic NADPH ?
A. Isocitrate dehydrogenase
B. ATP citrate lyase
C. Malic enzyme
D. G6PD
Answer: B
94. All are true regarding mitochondrial DNA, EXCEPT ?
A. Double stranded
B. Inherited from mother
C. High mutation rate
D. All respiratory proteins are synthesized within mitochondria
itself
Answer: D
95. Which apolipoprotein is responsible for Alzeihmers disease
A. APOE4
B. APOE3
C. APOE2
D. APOE1
Answer: A
96. Hyperammonaemia inhibit TCA cycle by depleting?
A. succinate
B. a keto glutarate
C. malate
D. fumarate
Answer: B
97. which amino acid is used to synthesise Nitric oxide ?
A. glycine
B. arginine
C. tyrosine
D. threonine
Answer: B
98. Menkes disease is associated with which enzyme deficiency.
A. lysyl oxidase
B. Methionine synthase
C. Glutamyl aminopeptidase
D. Lysyl hydroxylase
Answer: A
99. LCAT deficiency increases the following
A. HDL
B. LDL
C. VLDL
D. Chylomicron
Answer: A
100. A 25 year old alcoholic presented with edema, hypertension, ocular disturbance, and changes in mental state was observed, diagnosis of high output cardiac failure was made with Wet Beri Beri, this is due to deficiency of?
A. Vit B3
B. Vit B6
C. Vit B9
D. Vit B1
Answer: D
101. Glutamine is Increase in CSF, blood and urine, this is due to deficiency of
A. CPS-I
B. Arginase
C. OTC
D. Argininosuccinate synthetase
Answer: A
102. True about type 1 diabetes mellitus
A. Decreased protein catabolism
B. Decreased hepatic Glucose output
C. Increased lipolysis
D. Increase glucose uptake
Answer: C
103. Protein which is not synthesised In liver is
A. Phase protein
B. Immunoglobulins
C. Albumin
D. Plasma hormone
Answer: B
104. type of cholesterol present in gallstones?
A. Amorphous cholesterol monohydrate.
B. Amorphous cholesterol dihydrate.
C. Crystalline Cholesterol dihydrate.
D. Crystalline cholesterol monohydrate.
Answer: D
105. collagen present in skin is
A. Type II
B. Type I
C. Type III
D. Type IV
Answer: B
106. which of the following is not Ribozyme?
A. Ploy A polymerase
B. Ribonuclease
C. Transpeptidase
D. Peptidyl Transferase
Answer: A
107. Type-I hyperlipoproteinemia is characterized by
A. Elevated LDL
B. Elevated HDL
C. Elevated chylomicrons
D. Elevated lipoprotein lipase
Answer: C
108. In Kreb’s cycle and Urea cycle the linking amino acid is
A. Fumarate
B. Alanine
C. Arginine
D. Aspartate
Answer: D
109. The cofactor vitamin B12 is required for
the following conversion:
A. Dopamine to Norepinephrine
B. Propionyl CoA to methyl malonyl CoA
C. Methyl malonyl CoA to succinyl CoA
D. Cysteine to homocysteine
Answer: C
110. Which of the following enzyme activity decreases in fasting?
A. Hormone sensitive lipase
B. Glycogen phosphorylase
C. Acetyl CoA Carboxylase
D. Phosphofructokinase I
Answer: D
