1. Most effective agent to prevent motion sickness is?
A. Ephedrine
B. Nedocromil
C. Cyproheptidine
D. Hyoscine
Answer: D
2. Agent used for treatment of heparin induced thrombocytopenia ?
A. Lepirudin
B. Abciximab
C. Warfarin
D. Alteplase
Answer: A
3. Most commonly used cholinesterase regenerator at NM junction is ?
A. Pralidoxime
B. Obidxime
C. Diacetyl monoxime
D. Edrophonium
Answer: A
4. Maximum sterilising action is shown by which anti TB drug ?
A. Rifampicin
B. INH
C. Pyrazinamide
D. Streptomycin
Answer: A
5. Cyclic peptide chain is present in ?
A. Gramicidin A
B. Gramicidin B
C. Gramicidin D
D. Gramicidin S
Answer: D
6. Neuropsychiatry symptoms are seen with which anti TB drug ?
A. INH
B. Rifampicin
C. Pyrazinamide
D. Streptomycin
Answer: A
7. Maintenance dose is calculated by using value of?
A. Clearance
B. Volume of distribution
C. Oral bioavailability
D. Daily dosage
Answer: A
8. Anticancer drug with disulfuram like action
A. Procarbazine
B. Nitrosurea
C. 5 FU
D. Methotrexate
Answer: A
9. CB 1 antagonist used in smoking cessation is ?
A. Naloxona
B. Rimonabant
C. Vareniloline
D. Bupripion
Answer: B
10. IV diazepam has which of the following effect which is not seen by other routes ?
A. Analgesia
B. Sedation
C. Hypotension
D. Coronary dilatation
Answer: D
11. Bromocriptine is used in following clinical situations except ?
A. Type II DM
B. Hepatic Coma
C. Cyclical mastalgia
D. Hyperprolactinemia
Answer: D
12. Following is true about GnRH agonists except ?
A. Used in cases of precocious puberty
B. They have action similar to gonadotropin releasing hormone
C. Long acting preparations can be used as nasal spray
D. Ganirelix is the most potent agent
Answer: D
13. Female on carbimazole therapy presents with sudden fever, rigors and sore throat. Which is the investigation of choice for this patient?
A. Check blood counts
B. Check C reactive protein
C. Take throat Swab
D. Treat for malaria
Answer: A
14. Selective beta 2 blocker is ?
A. Butoxamine
B. Betoxolol
C. Esmolol
D. Bisoprolol
Answer: A
15. Beta blocker with membrane stabilizing property are all except ?
A. Acebutolol
B. Betaxolol
C. Carvedilol
D. Bevantolol
Answer: D
16. Longest acting beta blokeris ?
A. Nodalol
B. Esmolol
C. Carvedilol
D. Acebnolol
Answer: A
17. Bevacizumab is used in ?
A. Carcinoma colon
B. Liver carcinoma
C. Renal cell carcinoma
D. Pancreatic carcinoma
Answer: A
18. Cabergoline is used in
A. Acromegaly
B. Hyper prolactinoma
C. Both a and b
D. None of the above
Answer: C
19. Flu like symptoms is side effect of which anti TB drug ?
A. NH
B. Rifampicin
C. Pyrzinamide
D. Streptomycin
Answer: B
20. Which of the following SSRI is a prodrug?
A. Fluoxetine
B. Paroxetine
C. Citalopram
D. Fluvoxamine
Answer: A
21. Tamoxifen ?
A. SSRI
B. SERM
C. SNRI
D. DNRI
Answer: B
22. Letrozole belongs to which group?
A. SERM
B. SERD
C. LHRH analogues
D. Aromatse inhibitors
Answer: D
23. TADALAFIL false is ?
A. It is longest acting phosphodiesterase inhibitor
B. It cannot be used for the treatment of PAH
C. It is used in erectile dysfunction
D. Its half life is 17-5 hours
Answer: B
24. Amphetamine causes which of the following ?
A. IUGR
B. Cardiac anamoly
C. Cleft lip
D. All the above
Answer: D
25. Which of the following drugs is contraindicated in liver dysfunction?
A. Pefloxacin
B. Vancomycin
C. Amikacin
D. Hydralazine
Answer: A
26. Bevacizumab is ?
A. Anti VEGF antibody
B. Histone decyclase inhibitor
C. Proteasome inhibitor
D. Her2 neu inhibitor
Answer: A
27. Irreversible hearing loss caused by ?
A. Gentamycin
B. Clarithromycin
C. Both of the above
D. None of the above
Answer: A
28. Mechanism of action of colchicine is ?
A. Inhibits gouty inflammation
B. Inhbits the release of chemotactic factors
C. Inhibits granulocyte migration
D. All the above
Answer: D
29. Drug used in treatment of migraine ?
A. 5HT1 agonist
B. 5HT1 antagonist
C. Dl agonist
D. D1 antagonist
Answer: A
30. Drug of choice for MRSA infection ?
A. Ciprofloxacin
B. Oxacillin
C. Vancomycin
D. Clindamycin
Answer: C
31. Hypolipidemic drugs act on all except ?
A. HMG Co A reductase
B. Lipoprotein lipase
C. Acyl CoA, cholesterol acyl transferase 1
D. Peripheral decarboxylase
Answer: D
32. Following are the side effects of fenfluramine except ?
A. Pulmonary hypertension
B. Valvular defects
C. Sudden deaths
D. Dizziness
Answer: D
33. Cholinergic drug which acts on heart by decrease in levels of cAMP and due to opening of K+ channels is?
A. Methacholine
B. Oxotremorine
C. Bethanechol
D. DMPP
Answer: A
34. Pramlintide is ?
A. Synthetic amylin analogue
B. Inhibitor of DPP 4
C. GLP 1 analogue
D. PPAR gamma
Answer: A
35. Mannitol is not useful for ?
A. Glaucoma
B. Raised ICT
C. Impending renal failure
D. Pulmonary edema
Answer: D
36. Which anti TB drug is avoided in HIV patient ?
A. INH
B. Rifampicin
C. Pyrazinamide
D. Streptomycin
Answer: B
37. Vit K is available as all except ?
A. Menoquinone
B. Menadione
C. Phytonadione
D. Phyto quinone
Answer: D
38. Which of the following anticancer drugs are competitive inhibitors of tyrosine kinase ?
A. Imatinib and sunitinib
B. Letrozole
C. Bicalutamide
D. Fulvestrant
Answer: A
39. Thalidomide is used in ?
A. Mutilple myeloma
B. Squamous cell carcinoma
C. Basal cell carcinoma
D. Masopharyngeal carcinoma
Answer: A
40. Which drug prevent peripheral conversion of T4 to T3
A. Propylthiouracil
B. Propranolol
C. Iodides
D. a and b both
Answer: D
41. Daclizumab acts through ?
A. cGMP activation
B. Adenyl cyclase inhibition
C. IL 2 receptor blocker
D. IL10 receptor blocker
Answer: C
42. 1, 25 dihydrocholecalciferol acts on ?
A. Surface receptors
B. Cytosolic receptors
C. Intranuclear receptors
D. None of the above
Answer: C
43. Following is false about aripiprazole except ?
A. Only antipsychotic with D1 agonistic activity
B. It has 5HT1A antagonistic action
C. It has maximum sedating potential
D. It is the drug of choice in treatment of acute mania
Answer: D
44. Mechanism of action of actinomycin D is ?
A. Inhibits DNA dependent RNA synthesis
B. Activates DNA dependent RNA synthesis
C. Inhibits RNA dependent DNA synthesis
D. Activates RNA dependent DNA synthesis
Answer: A
45. Neostigmine is used in the following except ?
A. Myasthenia gravis
B. Cobra bite
C. Atony of bladder
D. Glaucoma
Answer: D
46. Xenobiotics are metabolized to ?
A. Increase water solubility
B. Increase lipid solubility
C. Make them nonpolar
D. None of the above
Answer: A
47. Dose of centchroman is ?
A. 30 mg
B. 60 mg
C. 120 mg
D. 240 mg
Answer: A
48. Pharmacoviglance is used for ?
A. To monitor drug toxicity
B. To monitor unauthorized drug manufacture
C. Monitoring of students
D. Check costs
Answer: A
49. Branch that deals with medicinal drugs obtained from plants and other natural resources
A. Pharmacognosy
B. Pharmacogenetics
C. Pharmacogenomics
D. Pharmacopia
Answer: A
50. Drugs causing peptic ulcer are all except ?
A. Clopidogrel
B. NSAID
C. Mycophenolate mofetil
D. Propylthiouracil
Answer: D
51. Which is the antidepressant with no anticholinergic effects?
A. Imipramine
B. Mianserine
C. Fluoxamine
D. Amitryptiline
Answer: C
52. Inverse agonist of benzodiazepine receptor is
A. Phenobarbitone
B. Flumazenil
C. Beta carboline
D. Gabapentin
Answer: C
53. Dantrolene acts on ?
A. Raynodine receptor
B. Cannabinoid receptor
C. Both of the above
D. None of the above
Answer: A
54. Colistin is obtained from ?
A. Bacteria
B. Fungi
C. Actinmycetes
D. Herbs
Answer: A
55. Drug not acting on P2y12 receptor is ?
A. Ticlopidine
B. Clopidrogel
C. Dipyridamole
D. Prasugrel
Answer: C
56. All release histamine except ?
A. Pancuronium
B. D- TC
C. Succinylcholine
D. Mivacurium
Answer: A
57. False regarding Cytochrome P 450 is ?
A. They are essential for the production of cholesterols, steroids, prostacyclins and thromboxane A2
B. They absorb light with 45nm wavelength
C. They occur predominantly in liver
D. They are non heme proteins
Answer: D
58. Omalizumab is ?
A. Anti IgM antibody
B. AntilgG antibody
C. Anti IgE antibody
D. Anti IgD antibody
Answer: C
59. Nicotinic acid ?
A. Increases HDL
B. Increased triglyceride synthesis
C. Type II hyperlipoproteinemia
D. Decreased hydrolysis of VLDL
Answer: A
60. HIV integrase inhibitor is ?
A. Elvitegravir
B. Abacavir
C. Maraviroc
D. Tenofovir
Answer: A
61. Platelet adhesion is inhibited by ?
A. Nitric oxide
B. Substance P
C. Thrombin
D. IL 2
Answer: A
62. Which of the following is the longest acting oral anticoagulant ?
A. Bishydroxycoumarin
B. Warfarin
C. Acenocoumarol
D. Phenindione
Answer: A
63. Function of M2 receptor in heart ?
A. SA node hyperpolarisation
B. AV node increased velocity of conduction
C. Increased contractility of ventricles
D. Increased Ach release from cholinergic nerve endings
Answer: A
64. Methysergide is banned as it causes ?
A. Pulmonary fibrosis
B. Pleural effusion
C. Syncope
D. Myocarditis
Answer: A
65. Dopamine at 1-2 Microgram/ Kg/ min produces?
A. Renal vasodilatation
B. Positive ionotropic effect
C. Mesenteric vasoconstriction
D. Generalised vasoconstriction
Answer: A
66. Which of the following is a univalent direct thrombin inhibitor?
A. Argatroban
B. Hirudin
C. Bivalirudin
D. Lepirudin
Answer: A
67. Treatment agent for scarlet fever is
A. Penicillin
B. Ciprofloxacin
C. Erythromycin
D. Chloramphenicol
Answer: A
68. Atomoxetine is used for ?
A. Nocturnal enuresis
B. ADHD
C. Temper tantrums
D. Patent ductus arteriosus
Answer: B
69. Which of the following can prolong QT interval?
A. Nalidixic acid
B. Ofloxacin
C. Gatifloxacin
D. Pefloxacin
Answer: C
70. Streptokinase causes increase in ?
A. Plasmin
B. Thrombin
C. Kallikrein
D. Angiotensin II
Answer: A
71. Beta blocker with d isomer responsible for beta blocker action is ?
A. Nebivolol
B. Timolol
C. Esmolol
D. Propranolol
Answer: A
72. Tocilizumab is antibody against ?
A. IL 2
B. IL 4
C. IL 6
D. IL 8
Answer: C
73. Fomepizole acts as antidote for ?
A. Methanol poisoning
B. Cannabis poisoning
C. Lead poisoning
D. Cadmium Poisoning
Answer: A
74. About rectal route true is ?
A. Used for irritant and unpleasant drugs
B. Cannot be used in unconscious patient
C. There is predictable absorption of drug
D. Diazepam cannot be given via rectal route of administration
Answer: A
75. Transdermal patch is not used for following drug?
A. GTN
B. Fentanyl
C. Nicotine
D. Naloxone
Answer: D
76. Buprenorphine partial agonist at which opioid receptor?
A. Mu
B. Kappa
C. Delta
D. Lambda
Answer: A
77. Treatment for impetigo ?
A. Dicloxacillin
B. Ciprofloxacin
C. Gentamycin
D. Amoxicillin and clavulanic acid
Answer: A
78. Following are the side effects of thiazides except?
A. Hypokalemia
B. Hypocalcemia
C. Hepatic coma
D. Impotence
Answer: B
79. Weight gain is seen with all of the following antipsychiatric medications except ?
A. Quetiapine
B. Risperidone
C. Clozapine
D. Molindone
Answer: D
80. Loading dose depends on ?
A. Volume of distribution
B. Elimination rate
C. Half life
D. Plasma volume
Answer: A
81. Which of the following drugs has both antihelminth and antiprotozoal activity ?
A. Nitazoxanide
B. Emetine
C. Chloroquine
D. Diloxanide furoate
Answer: A
82. Reason for hepatic involvement in oral contraceptives is ?
A. Estrogen
B. Progesterone
C. Estrogen +Progesterone
D. Mixed trace elements
Answer: A
83. A = ACE inhibitor, B = beta blocker, C = calcium channel blocker, D= diuretics. For elderly with hypertension antihypertensive drug of choice is ?
A. A or D
B. A or B
C. A or C
D. C or D
Answer: D
84. Which drug is used in amyotrophic lateral sclerosis?
A. Riluzole
B. Glatirame
C. Tacrine
D. Olanzapine
Answer: A
85. Rotigotine is ?
A. Dopamine agonist
B. Dopamine antagonist
C. GABA agonist
D. GABA antagonist
Answer: A
86. Counterfeit drug is ?
A. Fake medicine
B. Contains the wrong ingredient
C. They have active ingredient in wrong dose
D. All the above
Answer: D
87. Most common receptor for typical antipsychotics is ?
A. D1
B. D2
C. D3
D. D4
Answer: B
88. Incretin like function is seen in ?
A. Exenatide
B. Miglital
C. Poiglitazone
D. Repaglinide
Answer: A
89. Patient on treatment on carbidopa + levodopa for 10 yrs now has weaning off effect. What should be added to restore
action ?
A. Tolcapone
B. Amantadine
C. Rasagiline
D. Benzhexol
Answer: A
90. Which of these is not used for the treatment of typhoid ?
A. Chloramphenicol
B. Ciprofloxacin
C. Ceftriaxone
D. Cefixime
Answer: D
91. LT antagonists are used in asthma for ?
A. Along with beta agonists to reduce steroids
B. In place of beta blockers as sole therapy
C. Prophylactic therapy for mild to moderate asthma
D. Definitive therapy in acute attack of asthma
Answer: C
92. Which is a long acting insulin?
A. Lispro
B. Aspart
C. Glargine
D. Glulicine
Answer: C
93. Steroid with max mineralocorticoid activity ?
A. Fludrocortisone
B. DOCA
C. Prednisolone
D. Triamsinolone
Answer: A
94. Young child weighing 20 kg was given a drug in the dose 100mg/kg body weight. The plasma concentration of the drug is 2mg/ dl and the clearance is 200 ml/hr. What is the time required to reach steady state plasma concentration
A. 10 hrs
B. 20hrs
C. 30hrs
D. 40hrs
Answer: B
95. Patient on verapamil should not be given beta blocker as ?
A. Conduction block
B. Bronchospasm
C. Neurogenic shock
D. Anaphylaxis
Answer: A
96. Drug that decreases LpA in blood ?
A. Statin
B. Nicotinic acid
C. Ezetimibe
D. CETP inhibitors
Answer: B
97. Glucuronidation takes place in ?
A. Liver
B. RBC
C. Pancreas
D. Thyroid
Answer: A
98. Digitalis produces which of the following changes in ECG ?
A. Tall T waves
B. ST segment elevation
C. Prolonged QT interval
D. Prolonged PR interval
Answer: D
99. Antifungal which can be used orally but not iv is?
A. Voriconazole
B. Amphoterecin B
C. Terbinafine
D. None of the above
Answer: C
100. Mechanism of action tacrolimus is ?
A. Inhibition of calcineurin
B. Antimetabolite
C. mTOR inhibitor
D. Inhibition of DNA synthesis
Answer: A
101. Long acting corticosteroid is ?
A. Triamcinolone
B. Betamethasone
C. Hydrocortisone
D. Prednisolone
Answer: B
102. Plasma protein bound drug distributed in which compartment ?
A. Extracellular
B. Intravascular
C. Interstitial
D. Extravascular
Answer: B
